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Literature summary extracted from

  • Wang, L.L.; Lu, X.P.; Smagghe, G.; Meng, L.W.; Wang, J.J.
    Functional characterization of BdB1, a well-conserved carboxylesterase among tephritid fruit flies associated with malathion resistance in Bactrocera dorsalis (Hendel) (2017), Comp. Biochem. Physiol. C, 200, 1-8 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.1 gene EST1, DNA and amino acid sequence determination and analysis, exon-intron organization, sequence comparisons and phylogenetic analysis, quantitative reverse transcription PCR enzyme expression analysis, recombinant expression in Spodoptera frugiperda Sf9 insect cells Bactrocera dorsalis

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.1 additional information gene EST1, encoding BdB, is silenced by RNAi Bactrocera dorsalis

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.1 Bactrocera dorsalis A0A034VLA7 i.e. Dacus dorsalis, a malathion-resistant strain MR and a susceptible strain MS
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.1 abdomen
-
 Bactrocera dorsalis
-
3.1.1.1 fat body
-
 Bactrocera dorsalis
-
3.1.1.1 head
-
 Bactrocera dorsalis
-
3.1.1.1 malpighian tubule
-
 Bactrocera dorsalis
-
3.1.1.1 midgut high enzyme content Bactrocera dorsalis
-
3.1.1.1 additional information BdB1 is significantly more abundant in multiple tissues in the malathion-resistant strain, MR. Expression profiles of BdB1 in the MR and MS strains of Bacterocera dorsalis, overview. The transcripts of BdB1 are expressed 8.64fold higher in the whole body, 3.5fold higher in the head, 13.53fold higher in the midgut and 5.56fold higher in the fat body in the MR strain than those in the MS strain Bactrocera dorsalis
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3.1.1.1 thorax
-
 Bactrocera dorsalis
-

Synonyms

EC Number Synonyms Comment Organism
3.1.1.1 BdB1
-
 Bactrocera dorsalis
3.1.1.1 Est1
-
 Bactrocera dorsalis
3.1.1.1 esterase B1
-
 Bactrocera dorsalis

General Information

EC Number General Information Comment Organism
3.1.1.1 evolution phylogenetic analysis, BdB1 is classified into carboxylesterases clade B Bactrocera dorsalis
3.1.1.1 malfunction RNA interference (RNAi)-mediated knockdown of BdB1 significantly increases malathion susceptibility Bactrocera dorsalis
3.1.1.1 physiological function the well-conserved esterase B1 gene, BdB1, mediates malathion resistance development via gene upregulation with the use of a laboratory selected malathion-resistant strain (MR) of Bactrocera dorsalis. Enzyme BdB1 probably has the function of malathion detoxification Bactrocera dorsalis