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Literature summary extracted from

  • Yamazaki, Y.; Sezukuri, K.; Takada, J.; Kimura, S.; Ohmae, M.
    A novel chemoenzymatic synthesis of sulfated type 2 tumor-associated carbohydrate antigens by transglycosylation of sulfated Lewis X oxazoline catalyzed by keratanase II (2016), ChemBioChem, 17, 1879-1886 .
    View publication on PubMed

Application

EC Number Application Comment Organism
3.2.1.B43 medicine sulfated type 2 carbohydrate chains are known tumor-associated carbohydrate antigens (TACAs). The enzyme efficiently catalyzes the transglycosylation reaction of the sulfated Lewis X (Galbeta(1->4)[Fucalpha(1->3)]GlcNAc(6-OSO3-)) oxazoline derivative, thereby giving the su-Lex dimer as the main product in good yields Niallia circulans
3.2.1.B43 medicine sulfated type 2 carbohydrate chains are known tumor-associated carbohydrate antigens (TACAs). The enzyme efficiently catalyzes the transglycosylation reaction of the sulfated Lewis X (Galbeta(1->4)[Fucalpha(1->3)]GlcNAc(6-OSO3-)) oxazoline derivative, thereby giving the su-Lex dimer as the main product in good yields Bacillus sp. Ks36

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.B43 Bacillus sp. Ks36
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-
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3.2.1.B43 Niallia circulans
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-
-
3.2.1.B43 Niallia circulans KsT202
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.B43 additional information the enzyme efficiently catalyzes the transglycosylation reaction of the sulfated Lewis X (Gal-beta-(1->4)-[Fuc-alpha-(1->3)]-GlcNAc(6-OSO3-)) (su-Lex) soxazoline derivative, thereby giving the su-Lex dimer as the main product in good yields. Exclusive formation of the beta-(1->3) glycosidic bond Niallia circulans ?
-
 ?
3.2.1.B43 additional information the enzyme efficiently catalyzes the transglycosylation reaction of the sulfated Lewis X (Gal-beta-(1->4)-[Fuc-alpha-(1->3)]-GlcNAc(6-OSO3-)) (su-Lex) soxazoline derivative, thereby giving the su-Lex dimer as the main product in good yields. Exclusive formation of the beta-(1->3) glycosidic bond Bacillus sp. Ks36 ?
-
 ?
3.2.1.B43 additional information the enzyme efficiently catalyzes the transglycosylation reaction of the sulfated Lewis X (Gal-beta-(1->4)-[Fuc-alpha-(1->3)]-GlcNAc(6-OSO3-)) (su-Lex) soxazoline derivative, thereby giving the su-Lex dimer as the main product in good yields. Exclusive formation of the beta-(1->3) glycosidic bond Niallia circulans KsT202 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.B43 keratanase II
-
 Niallia circulans
3.2.1.B43 keratanase II
-
 Bacillus sp. Ks36