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Literature summary extracted from

  • Wahlang, B.; McClain, C.; Barve, S.; Gobejishvili, L.
    Role of cAMP and phosphodiesterase signaling in liver health and disease (2018), Cell. Signal., 49, 105-115 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 ASP9831
-
 Homo sapiens
3.1.4.53 Caffeine
-
 Homo sapiens
3.1.4.53 pentoxifylline
-
 Homo sapiens
3.1.4.53 resveratrol
-
 Homo sapiens
3.1.4.53 roflumilast
-
 Homo sapiens
3.1.4.53 theophylline
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.53 3',5'-cAMP + H2O Homo sapiens
-
 5'-AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.53 Hep-G2 cell
-
 Homo sapiens
-
3.1.4.53 hepatocyte
-
 Homo sapiens
-
3.1.4.53 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.53 cAMPspecific PDE
-
 Homo sapiens
3.1.4.53 PDE4 isoform Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.53 physiological function hepatic isoforms PDE4A, B and D play a causal role in the development of liver injury and fibrosis Homo sapiens