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Literature summary extracted from
- Luteolin enhances sarcoplasmic reticulum Ca2+-ATPase activity through p38 MAPK signaling thus improving rat cardiac function after ischemia/reperfusion (2017), Cell. Physiol. Biochem., 41, 999-1010 .
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.10 | luteolin | - |
Rattus norvegicus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.10 | phospholamban | - |
Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.2.2.10 | sarcoplasmic reticulum | - |
Rattus norvegicus | 16529 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.10 | ATP + H2O + Ca2+[side 1] | Rattus norvegicus | - |
ADP + phosphate + Ca2+[side 2] | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.10 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.2.2.10 | cardiomyocyte cell line | - |
Rattus norvegicus | - |
| 7.2.2.10 | heart | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.10 | ATP + H2O + Ca2+[side 1] | - |
Rattus norvegicus | ADP + phosphate + Ca2+[side 2] | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 7.2.2.10 | ? | x * 114000, SDS-PAGE | Rattus norvegicus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.10 | sarcoplasmic reticulum Ca2+-ATPase | - |
Rattus norvegicus |
| 7.2.2.10 | SERCA2a | - |
Rattus norvegicus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 7.2.2.10 | physiological function | luteolin enhances sarcoplasmic reticulum Ca2+-ATPase activity to improve systolic/diastolic function during ischemia/reperfusion in rat hearts and cardiomyocytes by attenuating the inhibitive effects of the p38 pathway on phospholamban | Rattus norvegicus |
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Release 2023.1 (January 2023)
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