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Literature summary extracted from

  • Ahyayauch, H.; Sot, J.; Collado, M.I.; Huarte, N.; Requejo-Isidro, J.; Alonso, A.; Goni, F.M.
    End-product diacylglycerol enhances the activity of PI-PLC through changes in membrane domain structure (2015), Biophys. J., 108, 1672-1682 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.11 diacylglycerol at 22°C, diacylglycerol at 33 mol% increases enzyme activity in mixtures of phosphatidylinositol with dimyristoyl phosphatidylcholine, distearoyl phosphatidylcholine, sphingomyelin, or galactosylceramide, but not in pure phosphatidylinositol bilayers Bacillus cereus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.11 0.058
-
 1-phosphatidyl-1D-myo-inositol in the presence of diacylglycerol and dimyristoyl phosphatidylcholine, at pH 7.5 and 39°C Bacillus cereus
3.1.4.11 0.08
-
 1-phosphatidyl-1D-myo-inositol in the presence of diacylglycerol and sphingomyelin, at pH 7.5 and 39°C Bacillus cereus
3.1.4.11 0.125
-
 1-phosphatidyl-1D-myo-inositol in the presence of diacylglycerol and distearoyl phosphatidylcholine, at pH 7.5 and 39°C Bacillus cereus
3.1.4.11 0.44
-
 1-phosphatidyl-1D-myo-inositol in the presence of diacylglycerol, at pH 7.5 and 39°C Bacillus cereus
3.1.4.11 0.93
-
 1-phosphatidyl-1D-myo-inositol at pH 7.5 and 39°C Bacillus cereus
3.1.4.11 18.7
-
 1-phosphatidyl-1D-myo-inositol in the presence of diacylglycerol and galactosylceramide, at pH 7.5 and 39°C Bacillus cereus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Bacillus cereus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 1-phosphatidyl-1D-myo-inositol + H2O
-
 Bacillus cereus 1D-myo-inositol 1-phosphate + diacylglycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 phosphatidylinositol-phospholipase C
-
 Bacillus cereus
3.1.4.11 PI-PLC
-
 Bacillus cereus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.11 39
-
-
 Bacillus cereus