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Literature summary extracted from

  • Sajid-Ur-Rehman, X.; Saeed, A.; Saddique, G.; Ali Channar, P.; Ali Larik, F.; Abbas, Q.; Hassan, M.; Raza, H.; Fattah, T.A.; Seo, S.Y.
    Synthesis of sulfadiazinyl acyl/aryl thiourea derivatives as calf intestinal alkaline phosphatase inhibitors, pharmacokinetic properties, lead optimization, Lineweaver-Burk plot evaluation and binding analysis (2018), Bioorg. Med. Chem., 26, 3707-3715 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.1 2,4-dichloro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
-
Bos taurus
3.1.3.1 2-chloro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
-
Bos taurus
3.1.3.1 3,5-dinitro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
-
Bos taurus
3.1.3.1 4-chloro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
-
Bos taurus
3.1.3.1 4-fluoro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
-
Bos taurus
3.1.3.1 4-methoxy-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
-
Bos taurus
3.1.3.1 ascorbic acid
-
Bos taurus
3.1.3.1 KH2PO4
-
Bos taurus
3.1.3.1 N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)acetamide
-
Bos taurus
3.1.3.1 N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)butyramide
-
Bos taurus
3.1.3.1 N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)heptanamide
-
Bos taurus
3.1.3.1 N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)octanamide
-
Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.1 0.833
-
4-nitrophenyl phosphate at pH 9.5 and 37°C Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.1 Bos taurus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.1 4-nitrophenyl phosphate + H2O
-
Bos taurus 4-nitrophenol + phosphate
-
?

Subunits

EC Number Subunits Comment Organism
3.1.3.1 ? x * 52300, calculated from amino acid sequence Bos taurus

Synonyms

EC Number Synonyms Comment Organism
3.1.3.1 IAP
-
Bos taurus
3.1.3.1 intestinal alkaline phosphatase
-
Bos taurus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.1.3.1 Bos taurus calculated from amino acid sequence
-
5.8

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.3.1 0.000251
-
at pH 9.5 and 37°C Bos taurus 4-chloro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
3.1.3.1 0.000344
-
at pH 9.5 and 37°C Bos taurus 2,4-dichloro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
3.1.3.1 0.000492
-
at pH 9.5 and 37°C Bos taurus N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)heptanamide
3.1.3.1 0.000896
-
at pH 9.5 and 37°C Bos taurus 3,5-dinitro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
3.1.3.1 0.001547
-
at pH 9.5 and 37°C Bos taurus 4-fluoro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
3.1.3.1 0.001636
-
at pH 9.5 and 37°C Bos taurus N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)butyramide
3.1.3.1 0.001704
-
at pH 9.5 and 37°C Bos taurus N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)octanamide
3.1.3.1 0.003291
-
at pH 9.5 and 37°C Bos taurus 4-methoxy-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
3.1.3.1 0.003458
-
at pH 9.5 and 37°C Bos taurus 2-chloro-N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)benzamide
3.1.3.1 0.004137
-
at pH 9.5 and 37°C Bos taurus KH2PO4
3.1.3.1 0.004256
-
at pH 9.5 and 37°C Bos taurus N-((4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)carbamothioyl)acetamide