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Literature summary extracted from

  • Nakayama, K.; Schwans, J.P.; Sorin, E.J.; Tran, T.; Gonzalez, J.; Arteaga, E.; McCoy, S.; Alvarado, W.
    Synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates, effective butyrylcholinesterase inhibitors (2017), Bioorg. Med. Chem., 25, 3171-3181 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.8 (dibutyl phosphoric) hypochlorous anhydride
-
Equus caballus
3.1.1.8 benzyl di-n-butyl phosphate
-
Equus caballus
3.1.1.8 butyl ethyl phenyl phosphate
-
Equus caballus
3.1.1.8 di-n-butyl 2-chlorophenyl phosphate irreversible inhibition Equus caballus
3.1.1.8 di-n-butyl 2-methylbenzyl phosphate
-
Equus caballus
3.1.1.8 di-n-butyl 2-methylphenyl phosphate reversible inhibition Equus caballus
3.1.1.8 di-n-butyl 2-naphthyl phosphate
-
Equus caballus
3.1.1.8 di-n-butyl 2-phenylethyl phosphate
-
Equus caballus
3.1.1.8 di-n-butyl 3,4,5-trimethylphenyl phosphate
-
Equus caballus
3.1.1.8 di-n-butyl 3,4-dimethylphenyl phosphate
-
Equus caballus
3.1.1.8 di-n-butyl 3,5-dimethylphenyl phosphate
-
Equus caballus
3.1.1.8 di-n-butyl 3-methylbenzyl phosphate
-
Equus caballus
3.1.1.8 di-n-butyl 3-methylphenyl phosphate reversible inhibition Equus caballus
3.1.1.8 di-n-butyl 4-methylbenzyl phosphate
-
Equus caballus
3.1.1.8 di-n-butyl 4-methylphenyl phosphate reversible inhibition Equus caballus
3.1.1.8 di-n-butyl naphthalen-1-yl phosphate
-
Equus caballus
3.1.1.8 di-n-butyl phenyl phosphate
-
Equus caballus
3.1.1.8 di-n-pentyl phenyl phosphate
-
Equus caballus
3.1.1.8 dicyclohexyl phenyl phosphate
-
Equus caballus
3.1.1.8 diethyl 2-naphthyl phosphate
-
Equus caballus
3.1.1.8 diethyl 3,5-dimethylphenyl phosphate
-
Equus caballus
3.1.1.8 diethyl phenyl phosphate
-
Equus caballus
3.1.1.8 dimethyl phenyl phosphate
-
Equus caballus
3.1.1.8 additional information synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates, effective butyrylcholinesterase inhibitors, overview. Analysis of enzyme binding structure, structure-function analysis, modeling Equus caballus
3.1.1.8 phenyl dipropyl phosphate
-
Equus caballus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Equus caballus P81908
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 commercial preparation
-
Equus caballus
-
3.1.1.8 serum
-
Equus caballus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 butyrylthiocholine + H2O
-
Equus caballus thiocholine + butyrate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 BChE
-
Equus caballus
3.1.1.8 butyrylcholinesterase
-
Equus caballus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.8 25
-
assay at Equus caballus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.8 7.5
-
assay at Equus caballus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.8 0.001
-
di-n-butyl 3,5-dimethylphenyl phosphate pH 7.5, 25°C Equus caballus
3.1.1.8 0.0019
-
di-n-butyl 2-naphthyl phosphate pH 7.5, 25°C Equus caballus
3.1.1.8 0.002
-
benzyl di-n-butyl phosphate pH 7.5, 25°C Equus caballus
3.1.1.8 0.008
-
di-n-butyl 4-methylphenyl phosphate pH 7.5, 25°C Equus caballus
3.1.1.8 0.009
-
di-n-butyl 3,4-dimethylphenyl phosphate pH 7.5, 25°C Equus caballus
3.1.1.8 0.011
-
di-n-butyl 3,4,5-trimethylphenyl phosphate pH 7.5, 25°C Equus caballus
3.1.1.8 0.014
-
di-n-butyl 4-methylbenzyl phosphate pH 7.5, 25°C Equus caballus
3.1.1.8 0.016
-
di-n-butyl 3-methylphenyl phosphate pH 7.5, 25°C Equus caballus
3.1.1.8 0.022
-
di-n-butyl naphthalen-1-yl phosphate pH 7.5, 25°C Equus caballus
3.1.1.8 0.024
-
di-n-butyl 3-methylbenzyl phosphate pH 7.5, 25°C Equus caballus
3.1.1.8 0.05
-
di-n-butyl 2-methylphenyl phosphate pH 7.5, 25°C Equus caballus
3.1.1.8 0.053
-
di-n-butyl 2-phenylethyl phosphate pH 7.5, 25°C Equus caballus
3.1.1.8 0.072
-
di-n-butyl 2-methylbenzyl phosphate pH 7.5, 25°C Equus caballus