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Literature summary extracted from

  • Rakesh, K.P.; Shantharam, C.S.; Manukumar, H.M.
    Synthesis and SAR studies of potent H+/K+-ATPase inhibitors of quinazolinone-Schiff's base analogues (2016), Bioorg. Chem., 68, 1-8 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.19 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'-(3,4,5-trihydroxybenzylidene)propanehydrazide
-
Ovis aries
7.2.2.19 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'-(3,4,5trimethoxybenzylidene)propanehydrazide
-
Ovis aries
7.2.2.19 3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
Ovis aries
7.2.2.19 4-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'(3,4,5trimethoxybenzylidene)butanehydrazide
-
Ovis aries
7.2.2.19 4-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'-(3,4,5-trihydroxybenzylidene)butanehydrazide
-
Ovis aries
7.2.2.19 4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
Ovis aries
7.2.2.19 N'-(2,3-dibromobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
-
Ovis aries
7.2.2.19 N'-(2,3-dibromobenzyliden)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
Ovis aries
7.2.2.19 N'-(2,4-dichlorobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
-
Ovis aries
7.2.2.19 N'-(2,4-dichlorobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
Ovis aries
7.2.2.19 N'-(2,4-difluorobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
-
Ovis aries
7.2.2.19 N'-(2,4-difluorobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
Ovis aries
7.2.2.19 N'-(2-chloro-6-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)butane hydrazide
-
Ovis aries
7.2.2.19 N'-(2-chloro-6-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
-
Ovis aries
7.2.2.19 N'-(2-fluoro-5-nitrobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
-
Ovis aries
7.2.2.19 N'-(2-fluoro-5-nitrobenzyliden)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
Ovis aries
7.2.2.19 N'-(3,4-dihydroxy-5-methoxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
Ovis aries
7.2.2.19 N'-(3,4-dihydroxy-5-methoxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
Ovis aries
7.2.2.19 N'-(4-chlorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
Ovis aries
7.2.2.19 N'-(4-chlorobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
Ovis aries
7.2.2.19 N'-(4-hydroxy-3-methoxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
Ovis aries
7.2.2.19 N'-(4-hydroxy-3-methoxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl) butanehydrazide
-
Ovis aries
7.2.2.19 N'-(4-hydroxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
Ovis aries
7.2.2.19 N'-(4-hydroxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
Ovis aries
7.2.2.19 N'-(4-methoxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
Ovis aries
7.2.2.19 N'-(4-methoxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
Ovis aries
7.2.2.19 N'-(4-nitrobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
Ovis aries
7.2.2.19 N'-(4-nitrobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
Ovis aries
7.2.2.19 N'-benzylidene-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
-
Ovis aries
7.2.2.19 N'-benzylidene-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
-
Ovis aries
7.2.2.19 N-(4-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)butane hydrazide
-
Ovis aries
7.2.2.19 N-(4-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
-
Ovis aries
7.2.2.19 Omeprazole
-
Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.19 ATP + H2O + H+[side 1] + K+[side 2] Ovis aries
-
ADP + phosphate + H+[side 2] + K+[side 1]
-
?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.19 Ovis aries
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.19 stomach
-
Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.19 ATP + H2O + H+[side 1] + K+[side 2]
-
Ovis aries ADP + phosphate + H+[side 2] + K+[side 1]
-
?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.19 H+/K+-ATPase
-
Ovis aries

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.2.2.19 0.01
-
at pH 7.5 and 37°C Ovis aries 4-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'-(3,4,5-trihydroxybenzylidene)butanehydrazide
7.2.2.19 0.014
-
at pH 7.5 and 37°C Ovis aries 4-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'(3,4,5trimethoxybenzylidene)butanehydrazide
7.2.2.19 0.015
-
at pH 7.5 and 37°C Ovis aries 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'-(3,4,5-trihydroxybenzylidene)propanehydrazide
7.2.2.19 0.022
-
at pH 7.5 and 37°C Ovis aries 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N'-(3,4,5trimethoxybenzylidene)propanehydrazide
7.2.2.19 0.024
-
at pH 7.5 and 37°C Ovis aries N'-(3,4-dihydroxy-5-methoxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
7.2.2.19 0.029
-
at pH 7.5 and 37°C Ovis aries N'-(3,4-dihydroxy-5-methoxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
7.2.2.19 0.032
-
at pH 7.5 and 37°C Ovis aries N'-(4-hydroxy-3-methoxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl) butanehydrazide
7.2.2.19 0.037
-
at pH 7.5 and 37°C Ovis aries N'-(4-hydroxy-3-methoxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
7.2.2.19 0.041
-
at pH 7.5 and 37°C Ovis aries N'-(4-methoxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
7.2.2.19 0.051
-
at pH 7.5 and 37°C Ovis aries N'-(4-hydroxybenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
7.2.2.19 0.054
-
at pH 7.5 and 37°C Ovis aries N'-(4-methoxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
7.2.2.19 0.06
-
at pH 7.5 and 37°C Ovis aries N'-(4-hydroxybenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
7.2.2.19 0.127
-
at pH 7.5 and 37°C Ovis aries N'-(4-nitrobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
7.2.2.19 0.129
-
at pH 7.5 and 37°C Ovis aries N'-(2-fluoro-5-nitrobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
7.2.2.19 0.131
-
at pH 7.5 and 37°C Ovis aries N'-(2,4-dichlorobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
7.2.2.19 0.134
-
at pH 7.5 and 37°C Ovis aries N'-(4-chlorobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
7.2.2.19 0.139
-
at pH 7.5 and 37°C Ovis aries N'-(2,3-dibromobenzyliden)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
7.2.2.19 0.14
-
at pH 7.5 and 37°C Ovis aries N'-(4-nitrobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
7.2.2.19 0.142
-
at pH 7.5 and 37°C Ovis aries N'-(2-fluoro-5-nitrobenzyliden)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
7.2.2.19 0.144
-
at pH 7.5 and 37°C Ovis aries N'-(2-chloro-6-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)butane hydrazide
7.2.2.19 0.146
-
at pH 7.5 and 37°C Ovis aries N'-(2,4-dichlorobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
7.2.2.19 0.151
-
at pH 7.5 and 37°C Ovis aries N'-(2,3-dibromobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
7.2.2.19 0.152
-
at pH 7.5 and 37°C Ovis aries N'-(4-chlorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
7.2.2.19 0.16
-
at pH 7.5 and 37°C Ovis aries N'-(2-chloro-6-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
7.2.2.19 0.16
-
at pH 7.5 and 37°C Ovis aries N-(4-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)butane hydrazide
7.2.2.19 0.169
-
at pH 7.5 and 37°C Ovis aries N'-(2,4-difluorobenzylidene)-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
7.2.2.19 0.17
-
at pH 7.5 and 37°C Ovis aries N-(4-fluorobenzylidene)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
7.2.2.19 0.18
-
at pH 7.5 and 37°C Ovis aries N'-(2,4-difluorobenzyliden)-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propane hydrazide
7.2.2.19 0.197
-
at pH 7.5 and 37°C Ovis aries N'-benzylidene-4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
7.2.2.19 0.21
-
at pH 7.5 and 37°C Ovis aries N'-benzylidene-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide
7.2.2.19 0.241
-
at pH 7.5 and 37°C Ovis aries 4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanehydrazide
7.2.2.19 0.248
-
at pH 7.5 and 37°C Ovis aries 3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanehydrazide