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Literature summary extracted from
- Design and evaluation of a phospholipase D based drug delivery strategy of novel phosphatidyl-prodrug (2017), Biomaterials, 131, 1-14 .
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.1.4.4 | medicine | design of a safe and simple amphiphilic prodrug delivery system, based on the elevated expression of phospholipase D in cancer cells. The method utilizes the transphosphatidylation ability of bacterial PLD on alcohol groups and the hydrolysis activity of overexpressed PLD on phospholipids in cancer cells. Phosphatidyl-doxorubicin is synthesized by bacterial PLD. The prodrug can be selfassembled to nanoparticles with uniform size and doxorubicin can be selectively released in cancer cells triggered by the locally overexpressed PLD. The method can significantly prolong the half-life of doxorubicin in the tumors and decrease the distribution in heart and kidney | Homo sapiens |
| 3.1.4.4 | medicine | design of a safe and simple amphiphilic prodrug delivery system, based on the elevated expression of phospholipase D in cancer cells. The method utilizes the transphosphatidylation ability of bacterial PLD on alcohol groups and the hydrolysis activity of overexpressed PLD on phospholipids in cancer cells. Phosphatidyl-doxorubicin is synthesized by bacterial PLD. The prodrug can be selfassembled to nanoparticles with uniform size and doxorubicin can be selectively released in cancer cells triggered by the locally overexpressed PLD. The method can significantly prolong the half-life of doxorubicin in the tumors and decrease the distribution in heart and kidney | Streptomyces chromofuscus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.4 | Homo sapiens | - |
- |
- |
| 3.1.4.4 | Streptomyces chromofuscus | Q8KRU5 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.4 | doxorubicin + phosphatidate | - |
Streptomyces chromofuscus | phosphatidyl-doxorubicin + H2O | - |
? |  |
| 3.1.4.4 | phosphatidyl-doxorubicin + H2O | - |
Homo sapiens | doxorubicin + phosphatidate | - |
? | |
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Release 2023.1 (January 2023)
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