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Literature summary extracted from

  • Wang, H.; Nair, V.S.; Holland, A.A.; Capolicchio, S.; Jessen, H.J.; Johnson, M.K.; Shears, S.B.
    Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity (2015), Biochemistry, 54, 6462-6474.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.B18 expression in Drosophila melanogaster Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.6.1.B18 additional information a recombinant Asp1 construct that contains the putative phosphatase domain residues Asp1371-920, is able to dephosphorylate substrates 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate and 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate Schizosaccharomyces pombe

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.B18 Homo sapiens Q6PFW1 bifunctional kinase/phosphatase, cf. EC 2.7.4.21, EC 2.7.4.24
-
3.6.1.B18 Schizosaccharomyces pombe O74429 bifunctional kinase/phosphatase, cf. EC 2.7.4.21, EC 2.7.4.24
-
3.6.1.B18 Schizosaccharomyces pombe 972 O74429 bifunctional kinase/phosphatase, cf. EC 2.7.4.21, EC 2.7.4.24
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.6.1.B18 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + 2 H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + 2 phosphate (2) Schizosaccharomyces pombe
a
3.6.1.B18 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate (1) Schizosaccharomyces pombe
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.B18 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + 2 H2O
-
 Schizosaccharomyces pombe 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + 2 phosphate
-
 ?
3.6.1.B18 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + 2 H2O
-
 Schizosaccharomyces pombe 972 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + 2 phosphate
-
 ?
3.6.1.B18 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O
-
 Homo sapiens 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate
-
 ?
3.6.1.B18 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O
-
 Schizosaccharomyces pombe 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate
-
 ?
3.6.1.B18 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O
-
 Schizosaccharomyces pombe 972 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate
-
 ?
3.6.1.B18 additional information enzyme specifically hydrolyzes the 1-diester phosphate of 1-InsP7 and 1,5-InsP8. No substrates are 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, 2-diphospho-1D-myo-inositol 1,3,4,5,6-pentakisphosphate, 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate, 4-diphospho-1D-myo-inositol 1,2,3,5,6-pentakisphosphate, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate, 6-diphospho-1D-myo-inositol 1,2,3,4,5-pentakisphosphate, or 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate Schizosaccharomyces pombe ?
-
 ?
3.6.1.B18 additional information no substrates are 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, 2-diphospho-1D-myo-inositol 1,3,4,5,6-pentakisphosphate, 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate, 4-diphospho-1D-myo-inositol 1,2,3,5,6-pentakisphosphate, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate, 6-diphospho-1D-myo-inositol 1,2,3,4,5-pentakisphosphate, or 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate Homo sapiens ?
-
 ?
3.6.1.B18 additional information enzyme specifically hydrolyzes the 1-diester phosphate of 1-InsP7 and 1,5-InsP8. No substrates are 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, 2-diphospho-1D-myo-inositol 1,3,4,5,6-pentakisphosphate, 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate, 4-diphospho-1D-myo-inositol 1,2,3,5,6-pentakisphosphate, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate, 6-diphospho-1D-myo-inositol 1,2,3,4,5-pentakisphosphate, or 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate Schizosaccharomyces pombe 972 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.B18 ASP1
-
 Schizosaccharomyces pombe
3.6.1.B18 ASP1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
3.6.1.B18 2Fe-2S-center presence of about 2 atoms of iron and acid-labile sulfide per Asp1 molecule. The [2Fe-2S]2+ cluster substantially inhibits the phosphatase activity of Asp1 Schizosaccharomyces pombe