EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.21.4.5 | 2,3,5,6-tetrachlorohydroquinone + 2 glutathione | Sphingobium chlorophenolicum | the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative | 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide | - |
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1.21.4.5 | 2,3,6-trichlorohydroquinone + 2 glutathione | Sphingobium chlorophenolicum | the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative | 2,6-dichlorohydroquinone + Cl- + glutathione disulfide | - |
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EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.21.4.5 | Sphingobium chlorophenolicum | Q03520 | - |
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EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.21.4.5 | 2,3,5,6-tetrachlorohydroquinone + 2 glutathione | the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative | Sphingobium chlorophenolicum | 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide | - |
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1.21.4.5 | 2,3,5,6-tetrachlorohydroquinone + 2 glutathione | the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone | Sphingobium chlorophenolicum | 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide | - |
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1.21.4.5 | 2,3,6-trichlorohydroquinone + 2 glutathione | the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative | Sphingobium chlorophenolicum | 2,6-dichlorohydroquinone + Cl- + glutathione disulfide | - |
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1.21.4.5 | 2,3,6-trichlorohydroquinone + 2 glutathione | the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. Binding of trichlorohydroquinone (TriCHQ) to the active site is followed by rapid deprotonation to form TriCHQ-2 and subsequent formation of 3,5,6-trichloro-4-hydroxycyclohexa-2,4-dienone. Further conversion of 3,5,6-trichloro-4-hydroxycyclohexa-2,4-dienone to 2,6-dichlorohydroquinone proceeds only in the presence of glutathione. Conversion of 3,5,6-trichloro-4-hydroxycyclohexa-2,4-dienone to 2,6-dichlorohydroquinone during the first turnover is quite rapid, occurring at about 25/s when the enzyme is saturated with TriCHQ and glutathione. The rate of subsequent turnovers is limited by the rate of the thiol-disulfide exchange reaction required to regenerate the free enzyme after turnover, a reaction that is intrinsically less difficult, but is hampered by premature binding of the aromatic substrate to the active site before the catalytic cycle is completed | Sphingobium chlorophenolicum | 2,6-dichlorohydroquinone + Cl- + glutathione disulfide | - |
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EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.21.4.5 | tetrachlorohydroquinone dehalogenase | - |
Sphingobium chlorophenolicum |