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Literature summary extracted from

  • Warner, J.R.; Lawson, S.L.; Copley, S.D.
    A mechanistic investigation of the thiol-disulfide exchange step in the reductive dehalogenation catalyzed by tetrachlorohydroquinone dehalogenase (2005), Biochemistry, 44, 10360-10368 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.4.5 2,3,5,6-tetrachlorohydroquinone + 2 glutathione Sphingobium chlorophenolicum the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol a widely used wood preservative 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
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 ?
1.21.4.5 2,3,6-trichlorohydroquinone + 2 glutathione Sphingobium chlorophenolicum the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative 2,6-dichlorohydroquinone + Cl- + glutathione disulfide
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.4.5 Sphingobium chlorophenolicum Q03520
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.4.5 2,3,5,6-tetrachlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol a widely used wood preservative Sphingobium chlorophenolicum 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
-
 ?
1.21.4.5 2,3,5,6-tetrachlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme binds the glutathione involved in the thioldisulfide exchange reaction very poorly and does not alter its pKa in order to improve its nucleophilicity. Remarkably, single-turnover kinetic studies show that the enzyme catalyzes this step by approximately 10000fold Sphingobium chlorophenolicum 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
-
 ?
1.21.4.5 2,3,6-trichlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative Sphingobium chlorophenolicum 2,6-dichlorohydroquinone + Cl- + glutathione disulfide
-
 ?
1.21.4.5 2,3,6-trichlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme binds the glutathione involved in the thioldisulfide exchange reaction very poorly and does not alter its pKa in order to improve its nucleophilicity. Remarkably, single-turnover kinetic studies show that the enzyme catalyzes this step by approximately 10000fold Sphingobium chlorophenolicum 2,6-dichlorohydroquinone + Cl- + glutathione disulfide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.4.5 TCHQ dehalogenase
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 Sphingobium chlorophenolicum

General Information

EC Number General Information Comment Organism
1.21.4.5 metabolism the enzyme is involved in degradation of pentachlorophenol Sphingobium chlorophenolicum