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Literature summary extracted from

  • Kiefer, P.M.; McCarthy, D.L.; Copley, S.D.
    The reaction catalyzed by tetrachlorohydroquinone dehalogenase does not involve nucleophilic aromatic substitution (2002), Biochemistry, 41, 1308-1314 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.21.4.5 C13S the mutant enzyme catalyzes only the initial steps in the reaction. In the absence of Cys13, the intermediate 3,5-dichloro-6-S-glutathionyl-4-hydroxycyclohexa-2,4-dienone decomposes to a mixture of products in a pH-dependent fashion Sphingobium chlorophenolicum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.4.5 2,3,5,6-tetrachlorohydroquinone + 2 glutathione Sphingobium chlorophenolicum the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
-
 ?
1.21.4.5 2,3,6-trichlorohydroquinone + 2 glutathione Sphingobium chlorophenolicum the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative 2,6-dichlorohydroquinone + Cl- + glutathione disulfide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.4.5 Sphingobium chlorophenolicum Q03520
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.4.5 2,3,5,6-tetrachlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative Sphingobium chlorophenolicum 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
-
 ?
1.21.4.5 2,3,5,6-tetrachlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The reaction does not involve nucleophilic aromatic substitution Sphingobium chlorophenolicum 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
-
 ?
1.21.4.5 2,3,6-trichlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative Sphingobium chlorophenolicum 2,6-dichlorohydroquinone + Cl- + glutathione disulfide
-
 ?
1.21.4.5 2,3,6-trichlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone Sphingobium chlorophenolicum 2,6-dichlorohydroquinone + Cl- + glutathione disulfide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.4.5 TCHQ dehalogenase
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 Sphingobium chlorophenolicum
1.21.4.5 tetrachlorohydroquinone dehalogenase
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 Sphingobium chlorophenolicum