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Literature summary extracted from

  • Wang, F.; He, Q.; Su, K.; Wei, T.; Xu, S.; Gu, L.
    Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase (2018), Biochem. J., 475, 191-205 .
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.4.59 crystal structure of the DHH/DHHA1 domain of GdpP, i.e. GdpP-C, and structures in complex with c-di-AMP, cyclic diguanosine monophosphate, and 5'-O-phosphonoadenylyl-(3'->5')-adenosine Staphylococcus aureus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.59 5'-O-phosphonoadenylyl-(3'->5')-adenosine product inhibition, competitive Staphylococcus aureus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.59 0.0997
-
 cyclic di-3',5'-adenylate pH 8.0, 37°C Staphylococcus aureus
3.1.4.59 0.145
-
 cyclic di-3',5'-adenylate pH 8.0, 37°C, presence of 0.02 mM 5'-O-phosphonoadenylyl-(3'->5')-adenosine Staphylococcus aureus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.59 Mn2+ CdpP-C exclusively utilizes Mn2+ Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.59 Staphylococcus aureus A0A0U1MUE2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.59 cyclic di-3',5'-adenylate + H2O
-
 Staphylococcus aureus 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
 ?
3.1.4.59 additional information enzyme does not hydrolyze product 5'-O-phosphonoadenylyl-(3'->5')-adenosine Staphylococcus aureus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.59 CdnD
-
 Staphylococcus aureus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.59 8.5
-
-
 Staphylococcus aureus