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Literature summary extracted from

  • Busnelli, M.; Manzini, S.; Parolini, C.; Escalante-Alcalde, D.; Chiesa, G.
    Lipid phosphate phosphatase 3 in vascular pathophysiology (2018), Atherosclerosis, 271, 156-165 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.4 lysophosphatidic acid + H2O Mus musculus LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids monoacylglycerol + phosphate
-
 ?
3.1.3.4 lysophosphatidic acid + H2O Homo sapiens LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids monoacylglycerol + phosphate
-
 ?
3.1.3.4 sphingosine-1-phosphate + H2O Mus musculus LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids sphingosine + phosphate
-
 ?
3.1.3.4 sphingosine-1-phosphate + H2O Homo sapiens LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids sphingosine + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Homo sapiens O14495
-
-
3.1.3.4 Mus musculus Q99JY8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 lysophosphatidic acid + H2O
-
 Mus musculus monoacylglycerol + phosphate
-
 ?
3.1.3.4 lysophosphatidic acid + H2O
-
 Homo sapiens monoacylglycerol + phosphate
-
 ?
3.1.3.4 lysophosphatidic acid + H2O LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids Mus musculus monoacylglycerol + phosphate
-
 ?
3.1.3.4 lysophosphatidic acid + H2O LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids Homo sapiens monoacylglycerol + phosphate
-
 ?
3.1.3.4 sphingosine-1-phosphate + H2O
-
 Mus musculus sphingosine + phosphate
-
 ?
3.1.3.4 sphingosine-1-phosphate + H2O
-
 Homo sapiens sphingosine + phosphate
-
 ?
3.1.3.4 sphingosine-1-phosphate + H2O LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids Mus musculus sphingosine + phosphate
-
 ?
3.1.3.4 sphingosine-1-phosphate + H2O LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids Homo sapiens sphingosine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 lipid phosphate phosphatase 3
-
 Mus musculus
3.1.3.4 lipid phosphate phosphatase 3
-
 Homo sapiens
3.1.3.4 LPP3
-
 Mus musculus
3.1.3.4 LPP3
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.3.4 malfunction LPP3 deficiency, specifically targeted at vascular cell types, induces endothelial permeability, promotes leukocyte adhesion to endothelial cells and stimulates smooth muscle cell proliferation. Hepatocyte-specific Plpp3 deficiency, by modulating the plasma lipidome, exacerbates atherosclerosis development in Apoe-/-x01mice Mus musculus
3.1.3.4 malfunction LPP3 deficiency, specifically targeted at vascular cell types, induces endothelial permeability, promotes leukocyte adhesion to endothelial cells, and stimulates smooth muscle cell proliferation Homo sapiens
3.1.3.4 physiological function LPP3 activity is crucial for vascular and heart development Mus musculus
3.1.3.4 physiological function LPP3 activity is crucial for vascular and heart development Homo sapiens
3.1.3.4 physiological function LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids Mus musculus
3.1.3.4 physiological function LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids Homo sapiens