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Literature summary extracted from

  • Zhang, Z.; Feige, J.N.; Chang, A.B.; Anderson, I.J.; Brodianski, V.M.; Vitreschak, A.G.; Gelfand, M.S.; Saier, M.H.
    A transporter of Escherichia coli specific for L- and D-methionine is the prototype for a new family within the ABC superfamily (2003), Arch. Microbiol., 180, 88-100 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.4.2.11 D-alanine 106% activity at 50 mM with D-methionine as substrate Escherichia coli
7.4.2.11 D-serine 118% activity at 50 mM with D-methionine as substrate Escherichia coli
7.4.2.11 D-threonine 115% activity at 50 mM with D-methionine as substrate Escherichia coli
7.4.2.11 L-serine 121% activity at 5 mM with L-methionine as substrate, 114% activity at 50 mM with D-methionine as substrate Escherichia coli
7.4.2.11 L-threonine 120% activity at 50 mM with D-methionine as substrate Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.4.2.11 D-alanine 94% residual activity at 5 mM with L-methionine as substrate Escherichia coli
7.4.2.11 D-leucine 98% residual activity at 5 mM with L-methionine as substrate, 90% residual activity at 50 mM with D-methionine as substrate Escherichia coli
7.4.2.11 D-methionine 92% residual activity at 5 mM with L-methionine as substrate, 23% residual activity at 50 mM with D-methionine as substrate Escherichia coli
7.4.2.11 D-serine 86% residual activity at 5 mM with L-methionine as substrate Escherichia coli
7.4.2.11 D-threonine 94% residual activity at 5 mM with L-methionine as substrate Escherichia coli
7.4.2.11 L-alanine 91% residual activity at 5 mM with L-methionine as substrate, 95% residual activity at 50 mM with D-methionine as substrate Escherichia coli
7.4.2.11 L-leucine 84% residual activity at 5 mM with L-methionine as substrate, 94% residual activity at 50 mM with D-methionine as substrate Escherichia coli
7.4.2.11 L-methionine 7% residual activity at 5 mM with L-methionine as substrate, 12% residual activity at 50 mM with D-methionine as substrate Escherichia coli
7.4.2.11 L-threonine 89% residual activity at 5 mM with L-methionine as substrate Escherichia coli
7.4.2.11 L-valine 77% residual activity at 5 mM with L-methionine as substrate, 81% residual activity at 50 mM with D-methionine as substrate Escherichia coli
7.4.2.11 N-formyl-L-methionine 39% residual activity at 5 mM with L-methionine as substrate, 25% residual activity at 50 mM with D-methionine as substrate Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.4.2.11 ATP + H2O + D-methionine-[methionine-binding protein][side 1] Escherichia coli
-
 ADP + phosphate + D-methionine[side 2] + [methionine-binding protein][side 1]
-
 ?
7.4.2.11 ATP + H2O + L-methionine-[methionine-binding protein][side 1] Escherichia coli
-
 ADP + phosphate + L-methionine[side 2] + [methionine-binding protein][side 1]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.4.2.11 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.4.2.11 ATP + H2O + D-methionine-[methionine-binding protein][side 1]
-
 Escherichia coli ADP + phosphate + D-methionine[side 2] + [methionine-binding protein][side 1]
-
 ?
7.4.2.11 ATP + H2O + L-methionine-[methionine-binding protein][side 1]
-
 Escherichia coli ADP + phosphate + L-methionine[side 2] + [methionine-binding protein][side 1]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.4.2.11 metD
-
 Escherichia coli
7.4.2.11 methionine uptake transporter
-
 Escherichia coli
7.4.2.11 MuT
-
 Escherichia coli

Expression

EC Number Organism Comment Expression
7.4.2.11 Escherichia coli MetJ is the pleiotropic methionine repressor protein that negatively control expression of the operon encoding the ABC-type methionine uptake system down