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Literature summary extracted from

  • Talluri, E.; Pancotto, L.; Ruggiero, P.; Scarselli, M.; Balducci, E.
    CagL from Helicobacter pylori has ADP-ribosylation activity and exerts partial protective efficacy in mice (2017), Arch. Biochem. Biophys., 635, 102-109 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.2.5 additional information all the amino-acids tested Asp, Arg, Cys, His, Gln, Thr, Glu and Ser, are unable to produce enhancement of hydrolysis Helicobacter pylori

Application

EC Number Application Comment Organism
3.2.2.5 medicine vaccination with CagL has protective efficacy in mice Helicobacter pylori

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.5 Helicobacter pylori
-
-
-
3.2.2.5 Helicobacter pylori Shi470
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.5 NAD+ + H2O
-
 Helicobacter pylori ADP-D-ribose + nicotinamide
-
 ?
3.2.2.5 NAD+ + H2O
-
 Helicobacter pylori Shi470 ADP-D-ribose + nicotinamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.5 CagL
-
 Helicobacter pylori

General Information

EC Number General Information Comment Organism
3.2.2.5 physiological function CagL from Shi470 is catalytically active showing ADP-ribosyltransferase, NAD-glycohydrolase, and auto-ADP-ribosylation activities Helicobacter pylori