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Literature summary extracted from

  • Nagata, R.; Fujihashi, M.; Kawamura, H.; Sato, T.; Fujita, T.; Atomi, H.; Miki, K.
    Structural study on the reaction mechanism of a free serine kinase involved in cysteine biosynthesis (2017), ACS Chem. Biol., 12, 1514-1523 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.226
-
 Thermococcus kodakarensis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.226 the overall structure is divided into two domains , with a large cleft in the AMP complex and in the ADP complex. The cleft is closed in the ternary product complex with O-phospho-L-serine and AMP. The closure may reorient the carboxyl group of E30 near to the Ogamma atom of Ser. The Ogamma atom may be deprotonated by E30 and attack the beta-phosphate of ADP to form O-phospho-L-serine Thermococcus kodakarensis

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.226 E30A substantial decrease in the activity Thermococcus kodakarensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.226 ADP + L-serine Thermococcus kodakarensis
-
 AMP + O-phospho-L-serine
-
 ?
2.7.1.226 ADP + L-serine Thermococcus kodakarensis ATCC BAA-918
-
 AMP + O-phospho-L-serine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.226 Thermococcus kodakarensis Q5JD03
-
-
2.7.1.226 Thermococcus kodakarensis ATCC BAA-918 Q5JD03
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.226 ADP + L-serine
-
 Thermococcus kodakarensis AMP + O-phospho-L-serine
-
 ?
2.7.1.226 ADP + L-serine
-
 Thermococcus kodakarensis ATCC BAA-918 AMP + O-phospho-L-serine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.226 serK
-
 Thermococcus kodakarensis

General Information

EC Number General Information Comment Organism
2.7.1.226 physiological function SerK is a free serine kinase involved in cysteine biosynthesis Thermococcus kodakarensis