Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tocchetti, G.N.; Rigalli, J.P.; Arana, M.R.; Villanueva, S.S.M.; Mottino, A.D.
    Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics (2016), Toxicol. Appl. Pharmacol., 303, 45-57 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.6.2.2 carbamazepine
-
 Homo sapiens
7.6.2.2 carbamazepine
-
 Rattus norvegicus
7.6.2.2 Phenobarbital
-
 Homo sapiens
7.6.2.2 Phenobarbital
-
 Rattus norvegicus
7.6.2.2 rifampicin
-
 Homo sapiens
7.6.2.2 rifampicin
-
 Rattus norvegicus
7.6.2.2 spironolactone
-
 Homo sapiens
7.6.2.2 spironolactone
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 genistein
-
 Homo sapiens
7.6.2.2 genistein
-
 Rattus norvegicus
7.6.2.2 glyceollins
-
 Homo sapiens
7.6.2.2 glyceollins
-
 Rattus norvegicus
7.6.2.2 indomethacin
-
 Homo sapiens
7.6.2.2 indomethacin
-
 Rattus norvegicus
7.6.2.2 poly(acrylic acid)cysteine
-
 Homo sapiens
7.6.2.2 poly(acrylic acid)cysteine
-
 Rattus norvegicus
7.6.2.2 probenecid
-
 Homo sapiens
7.6.2.2 probenecid
-
 Rattus norvegicus
7.6.2.2 tryptanthrin
-
 Homo sapiens
7.6.2.2 tryptanthrin
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 plasma membrane
-
 Homo sapiens 5886
-
7.6.2.2 plasma membrane
-
 Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 ATP + H2O + xenobiotic[side 1] Homo sapiens
-
 ADP + phosphate + xenobiotic[side 2]
-
 ?
7.6.2.2 ATP + H2O + xenobiotic[side 1] Rattus norvegicus
-
 ADP + phosphate + xenobiotic[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens Q92887
-
-
7.6.2.2 Rattus norvegicus Q92887
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 Caco-2 cell
-
 Homo sapiens
-
7.6.2.2 enterocyte
-
 Homo sapiens
-
7.6.2.2 enterocyte
-
 Rattus norvegicus
-
7.6.2.2 intestine
-
 Homo sapiens
-
7.6.2.2 intestine
-
 Rattus norvegicus
-
7.6.2.2 SW-480 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + 2,4-dinitrophenyl-S-glutathione[side 1]
-
 Homo sapiens ADP + phosphate + 2,4-dinitrophenyl-S-glutathione[side 2]
-
 ?
7.6.2.2 ATP + H2O + 2,4-dinitrophenyl-S-glutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + 2,4-dinitrophenyl-S-glutathione[side 2]
-
 ?
7.6.2.2 ATP + H2O + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 1]
-
 Homo sapiens ADP + phosphate + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 2]
-
 ?
7.6.2.2 ATP + H2O + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 1]
-
 Rattus norvegicus ADP + phosphate + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 2]
-
 ?
7.6.2.2 ATP + H2O + methotrexate[side 1]
-
 Homo sapiens ADP + phosphate + methotrexate[side 2]
-
 ?
7.6.2.2 ATP + H2O + methotrexate[side 1]
-
 Rattus norvegicus ADP + phosphate + methotrexate[side 2]
-
 ?
7.6.2.2 ATP + H2O + ochratoxin A[side 1]
-
 Homo sapiens ADP + phosphate + ochratoxin A[side 2]
-
 ?
7.6.2.2 ATP + H2O + ochratoxin A[side 1]
-
 Rattus norvegicus ADP + phosphate + ochratoxin A[side 2]
-
 ?
7.6.2.2 ATP + H2O + ritonavir[side 1]
-
 Homo sapiens ADP + phosphate + ritonavir[side 2]
-
 ?
7.6.2.2 ATP + H2O + ritonavir[side 1]
-
 Rattus norvegicus ADP + phosphate + ritonavir[side 2]
-
 ?
7.6.2.2 ATP + H2O + saquinavir[side 1]
-
 Homo sapiens ADP + phosphate + saquinavir[side 2]
-
 ?
7.6.2.2 ATP + H2O + saquinavir[side 1]
-
 Rattus norvegicus ADP + phosphate + saquinavir[side 2]
-
 ?
7.6.2.2 ATP + H2O + trans-resveratrol[side 1]
-
 Homo sapiens ADP + phosphate + trans-resveratrol[side 2]
-
 ?
7.6.2.2 ATP + H2O + trans-resveratrol[side 1]
-
 Rattus norvegicus ADP + phosphate + trans-resveratrol[side 2]
-
 ?
7.6.2.2 ATP + H2O + vinblastine[side 1]
-
 Homo sapiens ADP + phosphate + vinblastine[side 2]
-
 ?
7.6.2.2 ATP + H2O + vinblastine[side 1]
-
 Rattus norvegicus ADP + phosphate + vinblastine[side 2]
-
 ?
7.6.2.2 ATP + H2O + xenobiotic[side 1]
-
 Homo sapiens ADP + phosphate + xenobiotic[side 2]
-
 ?
7.6.2.2 ATP + H2O + xenobiotic[side 1]
-
 Rattus norvegicus ADP + phosphate + xenobiotic[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 ABCC2
-
 Homo sapiens
7.6.2.2 ABCC2
-
 Rattus norvegicus
7.6.2.2 MRP2
-
 Homo sapiens
7.6.2.2 MRP2
-
 Rattus norvegicus
7.6.2.2 multidrug resistance-associated protein 2
-
 Homo sapiens
7.6.2.2 multidrug resistance-associated protein 2
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
7.6.2.2 Homo sapiens resveratrol, 8-hydroxydaidzein. atorvastatin, epirubicin, ethanol, irinotecan, isopentanol, and topotecan downregulate enzyme mRNA expression down
7.6.2.2 Rattus norvegicus resveratrol, 8-hydroxydaidzein. atorvastatin, epirubicin, ethanol, irinotecan, isopentanol, and topotecan downregulate enzyme mRNA expression down
7.6.2.2 Homo sapiens erucin, glyceollins, soybean extract, sulforaphane, 5'-fluorouracil, bortezomib, bosentan, carbamazepine, cimetidine, cisplatin A, efavirenz, mitotane, obatoclax, pregnenolone-16alpha-carbonitrile, quinidine, saquinavirm spironolactone, vincristine, rifampicin, and tripanocide benznidazole induce enzyme mRNA expression up
7.6.2.2 Rattus norvegicus erucin, glyceollins, soybean extract, sulforaphane, 5'-fluorouracil, bortezomib, bosentan, carbamazepine, cimetidine, cisplatin A, efavirenz, mitotane, obatoclax, pregnenolone-16alpha-carbonitrile, quinidine, saquinavirm spironolactone, vincristine, rifampicin, and tripanocide benznidazole induce enzyme mRNA expression up