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Literature summary extracted from

  • Lin, Y.M.; Fu, Y.; Hegde, S.; Tang, Y.; Radhakrishnan, R.; Shi, X.Z.
    Microsomal prostaglandin E synthase-1 plays a critical role in long-term motility dysfunction after bowel obstruction (2018), Sci. Rep., 8, 8831 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.3 Cay 10526
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.3 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.3 Prostaglandin H2 Rattus norvegicus
-
 Prostaglandin E2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.3 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.3 colon
-
 Rattus norvegicus
-
5.3.99.3 gut
-
 Rattus norvegicus
-
5.3.99.3 smooth muscle cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.3 Prostaglandin H2
-
 Rattus norvegicus Prostaglandin E2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.3 microsomal prostaglandin E synthase-1
-
 Rattus norvegicus
5.3.99.3 mPGES
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
5.3.99.3 Rattus norvegicus the enzyme expression increases in the distended bowel during obstruction up

General Information

EC Number General Information Comment Organism
5.3.99.3 physiological function the enzyme plays a critical role in the continuous suppression of motor function in the post-bowel obstruction state Rattus norvegicus