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Literature summary extracted from

  • Kim, J.; Seo, H.M.; Bhatia, S.K.; Song, H.S.; Kim, J.H.; Jeon, J.M.; Choi, K.Y.; Kim, W.; Yoon, J.J.; Kim, Y.G.; Yang, Y.H.
    Production of itaconate by whole-cell bioconversion of citrate mediated by expression of multiple cis-aconitate decarboxylase (cadA) genes in Escherichia coli (2017), Sci. Rep., 7, 39768 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.6 Tween 80 Tween 80 at a concentration of 0.1% resulted in a slight (7%) increase in conversion activity Aspergillus terreus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.6 expressed in Escherichia coli BL21(DE3) cells Aspergillus terreus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.6 Fe2+
-
 Aspergillus terreus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.6 cis-aconitate Aspergillus terreus
-
 itaconate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.6 Aspergillus terreus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.6 cis-aconitate
-
 Aspergillus terreus itaconate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.6 CadA
-
 Aspergillus terreus
4.1.1.6 cis-aconitate decarboxylase
-
 Aspergillus terreus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.6 35
-
-
 Aspergillus terreus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
4.1.1.6 25 40 more than 60% activity at 25 and 40°C, about 90% activity at 30°C Aspergillus terreus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.6 5.5
-
-
 Aspergillus terreus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.1.1.6 5 8 about 20% activity at pH 5.0, 100% activity at pH 5.5, about 65% activity at pH 6.0, about 50% activity at pH 6.5, about 35% activity at pH 7.0, about 25% activity at pH 7.5, about 20% activity at pH 8.0 Aspergillus terreus