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Literature summary extracted from

  • Diemen, P.M.V.; Leneghan, D.B.; Brian, I.J.; Miura, K.; Long, C.A.; Milicic, A.; Biswas, S.; Rollier, C.S.; Wyllie, D.H.
    The S. aureus 4-oxalocrotonate tautomerase SAR1376 enhances immune responses when fused to several antigens (2017), Sci. Rep., 7, 1745 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.2.6 expressed in Pichia pastoris Staphylococcus aureus

Protein Variants

EC Number Protein Variants Comment Organism
5.3.2.6 P1A inactive Staphylococcus aureus
5.3.2.6 R35A the mutation disrupts catalysis and impairs protein multimerisation Staphylococcus aureus
5.3.2.6 R35Q the mutation disrupts catalysis and impairs protein multimerisation Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.2.6 (2Z,4E)-2-hydroxyhexa-2,4-dienedioate Staphylococcus aureus
-
 (3E)-2-oxohex-3-enedioate
-
 r
5.3.2.6 (2Z,4E)-2-hydroxyhexa-2,4-dienedioate Staphylococcus aureus MRSA252
-
 (3E)-2-oxohex-3-enedioate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.3.2.6 Staphylococcus aureus Q6GH41
-
-
5.3.2.6 Staphylococcus aureus MRSA252 Q6GH41
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.2.6 (2Z,4E)-2-hydroxyhexa-2,4-dienedioate
-
 Staphylococcus aureus (3E)-2-oxohex-3-enedioate
-
 r
5.3.2.6 (2Z,4E)-2-hydroxyhexa-2,4-dienedioate
-
 Staphylococcus aureus MRSA252 (3E)-2-oxohex-3-enedioate
-
 r

Synonyms

EC Number Synonyms Comment Organism
5.3.2.6 4-OT
-
 Staphylococcus aureus
5.3.2.6 4-oxalocrotonate tautomerase
-
 Staphylococcus aureus
5.3.2.6 SAR1376
-
 Staphylococcus aureus