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Literature summary extracted from

  • Yoshinari, S.; Liu, Y.; Gollnick, P.; Ho, C.K.
    Cleavage of 3'-terminal adenosine by archaeal ATP-dependent RNA ligase (2017), Sci. Rep., 7, 11662 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.5.1.3 expressed in Escherichia coli BL21(DE3) cells Methanothermobacter thermautotrophicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.3 ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m Methanothermobacter thermautotrophicus
-
 (ribonucleotide)n+m + AMP + diphosphate
-
 ?
6.5.1.3 ATP + [RNA ligase]-L-lysine Methanothermobacter thermautotrophicus
-
 [RNA ligase]-N6-(5'-adenylyl)-L-lysine + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.3 Methanothermobacter thermautotrophicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.5.1.3
-
 Methanothermobacter thermautotrophicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.3 ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m
-
 Methanothermobacter thermautotrophicus (ribonucleotide)n+m + AMP + diphosphate
-
 ?
6.5.1.3 ATP + [RNA ligase]-L-lysine
-
 Methanothermobacter thermautotrophicus [RNA ligase]-N6-(5'-adenylyl)-L-lysine + diphosphate
-
 ?
6.5.1.3 additional information the enzyme catalyzes formation of phosphodiester bonds between the 5'-phosphate and 3'-hydroxyl termini of single-stranded RNAs. It can also react with RNA with a 3'-phosphate end to generate a 2',3'-cyclic phosphate. The enzyme can additionally remove adenosine from the 3'-terminus of the RNA to produce 3'-deadenylated RNA Methanothermobacter thermautotrophicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.3 ATP-dependent RNA ligase
-
 Methanothermobacter thermautotrophicus
6.5.1.3 RNL
-
 Methanothermobacter thermautotrophicus