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Literature summary extracted from

  • Omotayo, T.I; Akinyemi, G.S.; Omololu, P.A.; Ajayi, B.O.; Akindahunsi, A.A.; Rocha, J.B.; Kade, I.J.
    Possible involvement of membrane lipids peroxidation and oxidation of catalytically essential thiols of the cerebral transmembrane sodium pump as component mechanisms of iron-mediated oxidative stress-linked dysfunction of the pump's activity (2014), Redox Biol., 4, 234-241 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.3 Fe2+ dithiothreitol exerts considerable protective effect on the activity of the Fe2+-inhibited enzyme Rattus norvegicus
7.2.2.3 malondialdehyde
-
 Rattus norvegicus
7.2.2.3 additional information not inhibited by vitamin E Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.3 membrane transmembrane protein Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.3 ATP + H2O + Na+[side 1] Rattus norvegicus
-
 ADP + phosphate + Na+[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.3 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.3 cerebrum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.3 ATP + H2O + K+[side 1]
-
 Rattus norvegicus ADP + phosphate + K+[side 2]
-
 ?
7.2.2.3 ATP + H2O + Na+[side 1]
-
 Rattus norvegicus ADP + phosphate + Na+[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.3 Na+/K+-ATPase
-
 Rattus norvegicus
7.2.2.3 sodium pump
-
 Rattus norvegicus