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Literature summary extracted from

  • Nandy, A.; Saenz-Mendez, P.; Gorman, A.M.; Samali, A.; Eriksson, L.A.
    Homology model of the human tRNA splicing ligase RtcB (2017), Proteins, 85, 1983-1993 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
6.5.1.8 C122A the mutant does not bind Mn2+ Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.5.1.8 Mn2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.8 (ribonucleotide)n-2',3'-cyclophosphate + 5'-hydroxy-(ribonucleotide)m + GTP + H2O Homo sapiens
-
 (ribonucleotide)n+m + GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.8 Homo sapiens Q9Y3I0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.8 (ribonucleotide)n-2',3'-cyclophosphate + 5'-hydroxy-(ribonucleotide)m + GTP + H2O
-
 Homo sapiens (ribonucleotide)n+m + GMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.8 rtcB
-
 Homo sapiens
6.5.1.8 tRNA splicing ligase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.5.1.8 GTP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
6.5.1.8 physiological function the enzyme operates during the unfolded protein response Homo sapiens