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Literature summary extracted from

  • Brock, J.S.; Hamberg, M.; Balagunaseelan, N.; Goodman, M.; Morgenstern, R.; Strandback, E.; Samuelsson, B.; Rinaldo-Matthis, A.; Haeggstroem, J.Z.
    A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E2 synthase (2016), Proc. Natl. Acad. Sci. USA, 113, 972-977 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.99.3 expressed in Pichia pastoris Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
5.3.99.3 D49N the mutant shows severely reduced activity compared to the wild type enzyme Homo sapiens
5.3.99.3 R126K the mutant shows severely reduced activity compared to the wild type enzyme Homo sapiens
5.3.99.3 R126Q the mutant shows severely reduced activity compared to the wild type enzyme Homo sapiens
5.3.99.3 S127A the mutant shows about wild type activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.3 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.3 Prostaglandin H2 Homo sapiens
-
 Prostaglandin E2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.3 Homo sapiens O14684
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.99.3 Ni-affinity column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.3 Prostaglandin H2
-
 Homo sapiens Prostaglandin E2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.3 microsomal prostaglandin E2 synthase type 1
-
 Homo sapiens
5.3.99.3 mPGES-1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.3.99.3 glutathione dependent on Homo sapiens