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Literature summary extracted from

  • Majtan, T.; Pey, A.L.; Fernandez, R.; Fernandez, J.A.; Martinez-Cruz, L.A.; Kraus, J.P.
    Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases (2014), PLoS ONE, 9, e105290 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.22 expression in Escherichia coli Drosophila melanogaster
4.2.1.22 expression in Escherichia coli Homo sapiens
4.2.1.22 expression in Escherichia coli Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.22 Drosophila melanogaster
-
-
-
4.2.1.22 Homo sapiens
-
-
-
4.2.1.22 Saccharomyces cerevisiae
-
-
-

General Information

EC Number General Information Comment Organism
4.2.1.22 physiological function comparison of human, fruit fly and yeast enzymes. The fruit fly CBS and yeast CBS are not regulated by the allosteric activator of human CBS, S-adenosyl-L-methionine. The heme-containing Drosophila melanogaster CBS and human CBS show increased thermal stability and retention of the enzyme's catalytic activity Drosophila melanogaster
4.2.1.22 physiological function comparison of human, fruit fly and yeast enzymes. Truncation of human CBS and yeast CBS, i.e. deletion of the regulatory domains, results in enzyme activation and formation of dimers compared to native tetramers The fruit fly CBS and yeast CBS are not regulated by the allosteric activator of human CBS, S-adenosyl-L-methionine. compared to the yeast CBS, the heme-containing Drosophila melanogaster CBS and human CBS show increased thermal stability and retention of the enzyme's catalytic activity Saccharomyces cerevisiae
4.2.1.22 physiological function comparison of human, fruit fly and yeast enzymes. Truncation of human CBS and yeast CBS, i.e. deletion of the regulatory domains, results in enzyme activation and formation of dimers compared to native tetramers. Only the human enzyme is regulated by S-adenosylmethionine. The heme-containing Drosophila melanogaster CBS and human CBS show increased thermal stability and retention of the enzyme's catalytic activity Homo sapiens