Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kschowak, M.J.; Wortmann, H.; Dickschat, J.S.; Schrader, J.; Buchhaupt, M.
    Heterologous expression of 2-methylisoborneol / 2 methylenebornane biosynthesis genes in Escherichia coli yields novel C11-terpenes (2018), PLoS ONE, 13, e0196082 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
4.2.3.118 additional information usage of Escherichia coli strain MG1655 and derivatives for heterologous production of different C11-terpene synthases together with the GPP methyltransferase and the mevalonate pathway enzymes, 35 different C11-terpenes can be produced, overview Streptomyces coelicolor
4.2.3.118 additional information usage of Escherichia coli strain MG1655 and derivatives for heterologous production of different C11-terpene synthases together with the GPP methyltransferase and the mevalonate pathway enzymes, 35 different C11-terpenes can be produced, overview Streptomyces griseus subsp. griseus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.118 (E)-2-methylgeranyl diphosphate + H2O Streptomyces coelicolor
-
 2-methylisoborneol + diphosphate
-
 ?
4.2.3.118 (E)-2-methylgeranyl diphosphate + H2O Streptomyces griseus subsp. griseus
-
 2-methylisoborneol + diphosphate
-
 ?
4.2.3.118 (E)-2-methylgeranyl diphosphate + H2O Streptomyces coelicolor ATCC BAA-471 / A3(2) / M145
-
 2-methylisoborneol + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.118 Streptomyces coelicolor Q9F1Y6
-
-
4.2.3.118 Streptomyces coelicolor ATCC BAA-471 / A3(2) / M145 Q9F1Y6
-
-
4.2.3.118 Streptomyces griseus subsp. griseus Q9F1V8
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.2.3.118 (E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate catalytic mechanism, overview Streptomyces coelicolor
a
4.2.3.118 (E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate catalytic mechanism, overview Streptomyces griseus subsp. griseus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.118 (E)-2-methylgeranyl diphosphate + H2O
-
 Streptomyces coelicolor 2-methylisoborneol + diphosphate
-
 ?
4.2.3.118 (E)-2-methylgeranyl diphosphate + H2O
-
 Streptomyces griseus subsp. griseus 2-methylisoborneol + diphosphate
-
 ?
4.2.3.118 (E)-2-methylgeranyl diphosphate + H2O
-
 Streptomyces coelicolor ATCC BAA-471 / A3(2) / M145 2-methylisoborneol + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.118 2-MIB synthase
-
 Streptomyces coelicolor
4.2.3.118 2-MIB synthase
-
 Streptomyces griseus subsp. griseus
4.2.3.118 MIBSg
-
 Streptomyces coelicolor
4.2.3.118 MIBSg
-
 Streptomyces griseus subsp. griseus

General Information

EC Number General Information Comment Organism
4.2.3.118 physiological function 2-methylisoborneol (2-MIB) has a muddy smell with a low odor and flavor threshold and is a contaminant of drinking water, wine and fish. Moreover it is related to the musty-earthy aroma in camembert and brie Streptomyces coelicolor
4.2.3.118 physiological function 2-methylisoborneol (2-MIB) has a muddy smell with a low odor and flavor threshold and is a contaminant of drinking water, wine and fish. Moreover it is related to the musty-earthy aroma in camembert and brie Streptomyces griseus subsp. griseus