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Literature summary extracted from

  • Citro, V.; Cimmaruta, C.; Liguori, L.; Viscido, G.; Cubellis, M.V.; Andreotti, G.
    A mutant of phosphomannomutase1 retains full enzymatic activity, but is not activated by IMP Possible implications for the disease PMM2-CDG (2017), PLoS ONE, 12, e0189629 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.4.2.8 D-Glucose 1,6-bisphosphate
-
 Homo sapiens
5.4.2.8 D-Mannose 1,6-bisphosphate
-
 Homo sapiens
5.4.2.8 inosine monophosphate the phosphatase activity of isoform PMM1 is enhanced by inosine monophosphate Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.2.8 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.2.8 clodronate specific inhibitor; specific inhibitor Homo sapiens
5.4.2.8 inosine monophosphate inhibits competitively the mutase activity of isoform PMM1 Homo sapiens
5.4.2.8 additional information not inhibited by neridronate; not inhibited by neridronate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.4.2.8 0.0065
-
 alpha-D-mannose 1-phosphate isoform PMM1, at pH 7.5 and 32°C Homo sapiens
5.4.2.8 0.0073
-
 alpha-D-glucose 1-phosphate isoform PMM1, at pH 7.5 and 32°C Homo sapiens
5.4.2.8 0.0082
-
 alpha-D-glucose 1-phosphate isoform PMM2, at pH 7.5 and 32°C Homo sapiens
5.4.2.8 0.0237
-
 alpha-D-mannose 1-phosphate isoform PMM2, at pH 7.5 and 32°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.4.2.8 Homo sapiens O15305
-
-
5.4.2.8 Homo sapiens Q92871
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.2.8
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.2.8 alpha-D-glucose 1-phosphate
-
 Homo sapiens D-glucose 6-phosphate
-
 ?
5.4.2.8 alpha-D-mannose 1-phosphate
-
 Homo sapiens D-mannose 6-phosphate
-
 ?
5.4.2.8 additional information D-glucose 1,6-bisphosphate and D-mannose 1,6-bisphosphate can be hydrolyzed by isoform PMM1 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.4.2.8 phosphomannomutase 1
-
 Homo sapiens
5.4.2.8 phosphomannomutase 2
-
 Homo sapiens
5.4.2.8 PMM1
-
 Homo sapiens
5.4.2.8 PMM2
-
 Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
5.4.2.8 43
-
 melting temperature of isoform PMM1 Homo sapiens