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Literature summary extracted from

  • Gupta, R.S.; Nanda, A.; Khadka, B.
    Novel molecular, structural and evolutionary characteristics of the phosphoketolases from bifidobacteria and Coriobacteriales (2017), PLoS ONE, 12, e0172176 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.22 D-Fructose 6-phosphate + phosphate Bifidobacterium bifidum
-
 Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
 ?
4.1.2.22 D-Fructose 6-phosphate + phosphate Bifidobacterium breve
-
 Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
 ?
4.1.2.22 D-Fructose 6-phosphate + phosphate Bifidobacterium animalis
-
 Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
 ?
4.1.2.22 D-Fructose 6-phosphate + phosphate Bifidobacterium longum
-
 Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
 ?
4.1.2.22 D-Fructose 6-phosphate + phosphate Bifidobacterium reuteri
-
 Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
 ?
4.1.2.22 D-Xylulose 5-phosphate + phosphate Bifidobacterium bifidum
-
 Acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O
-
 ?
4.1.2.22 D-Xylulose 5-phosphate + phosphate Bifidobacterium breve
-
 Acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O
-
 ?
4.1.2.22 D-Xylulose 5-phosphate + phosphate Bifidobacterium animalis
-
 Acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O
-
 ?
4.1.2.22 D-Xylulose 5-phosphate + phosphate Bifidobacterium longum
-
 Acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O
-
 ?
4.1.2.22 D-Xylulose 5-phosphate + phosphate Bifidobacterium reuteri
-
 Acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.9 Bifidobacterium longum Q6R2Q7
-
-
4.1.2.22 Bifidobacterium animalis
-
-
-
4.1.2.22 Bifidobacterium bifidum
-
-
-
4.1.2.22 Bifidobacterium breve
-
-
-
4.1.2.22 Bifidobacterium longum Q6R2Q7
-
-
4.1.2.22 Bifidobacterium reuteri
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.22 D-Fructose 6-phosphate + phosphate
-
 Bifidobacterium bifidum Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
 ?
4.1.2.22 D-Fructose 6-phosphate + phosphate
-
 Bifidobacterium breve Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
 ?
4.1.2.22 D-Fructose 6-phosphate + phosphate
-
 Bifidobacterium animalis Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
 ?
4.1.2.22 D-Fructose 6-phosphate + phosphate
-
 Bifidobacterium longum Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
 ?
4.1.2.22 D-Fructose 6-phosphate + phosphate
-
 Bifidobacterium reuteri Acetyl phosphate + D-erythrose 4-phosphate + H2O
-
 ?
4.1.2.22 D-Xylulose 5-phosphate + phosphate
-
 Bifidobacterium bifidum Acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O
-
 ?
4.1.2.22 D-Xylulose 5-phosphate + phosphate
-
 Bifidobacterium breve Acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O
-
 ?
4.1.2.22 D-Xylulose 5-phosphate + phosphate
-
 Bifidobacterium animalis Acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O
-
 ?
4.1.2.22 D-Xylulose 5-phosphate + phosphate
-
 Bifidobacterium longum Acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O
-
 ?
4.1.2.22 D-Xylulose 5-phosphate + phosphate
-
 Bifidobacterium reuteri Acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.2.9 X5P/F6P phosphoketolase
-
 Bifidobacterium longum
4.1.2.9 XFPK
-
 Bifidobacterium longum
4.1.2.22 F6P phosphoketolase
-
 Bifidobacterium bifidum
4.1.2.22 F6P phosphoketolase
-
 Bifidobacterium breve
4.1.2.22 F6P phosphoketolase
-
 Bifidobacterium animalis
4.1.2.22 F6P phosphoketolase
-
 Bifidobacterium longum
4.1.2.22 F6P phosphoketolase
-
 Bifidobacterium reuteri
4.1.2.22 XFPK the bifunctional enzyme carries out the phosphorolysis of both D-fructose 6-phosphate and D-xylulose 5-phosphate Bifidobacterium bifidum
4.1.2.22 XFPK the bifunctional enzyme carries out the phosphorolysis of both D-fructose 6-phosphate and D-xylulose 5-phosphate Bifidobacterium breve
4.1.2.22 XFPK the bifunctional enzyme carries out the phosphorolysis of both D-fructose 6-phosphate and D-xylulose 5-phosphate Bifidobacterium animalis
4.1.2.22 XFPK the bifunctional enzyme carries out the phosphorolysis of both D-fructose 6-phosphate and D-xylulose 5-phosphate Bifidobacterium longum
4.1.2.22 XFPK the bifunctional enzyme carries out the phosphorolysis of both D-fructose 6-phosphate and D-xylulose 5-phosphate Bifidobacterium reuteri

General Information

EC Number General Information Comment Organism
4.1.2.9 metabolism members from the order Bifidobacteriales differ from all other organisms in using a unique pathway for carbohydrate metabolism, known as the "bifid shunt", which utilizes the enzyme phosphoketolase to carry out the phosphorolysis of both fructose-6-phosphate and xylulose-5-phosphate. The existence of the bifid shunt allows bifidobacteria to produce more ATP from carbohydrates than through other conventional pathways. In contrast to bifidobacteria, the phosphoketolases found in other organisms (referred to XPK) are able to metabolize primarily xylulose-5-phosphate and show very little activity towards fructose-6-phosphate Bifidobacterium longum