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Literature summary extracted from

  • Kaur, P.; Tripathi, N.; Desale, J.; Neelagiri, S.; Yadav, S.; Bharatam, P.; Singh, S.
    Mutational and structural analysis of conserved residues in ribose-5-phosphate isomerase B from Leishmania donovani Role in substrate recognition and conformational stability (2016), PLoS ONE, 11, e0150764 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.1.6
-
Leishmania donovani

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.3.1.6 homology modeling of wild type and mutants Leishmania donovani

Protein Variants

EC Number Protein Variants Comment Organism
5.3.1.6 C69S complete loss of enzyme activity, altered protein structure Leishmania donovani
5.3.1.6 D45N complete loss of enzyme activity, altered protein structure Leishmania donovani
5.3.1.6 E149A complete loss of enzyme activity, altered protein structure Leishmania donovani
5.3.1.6 H102N complete loss of enzyme activity, altered protein structure Leishmania donovani
5.3.1.6 H11N 10.7% loss of enzyme activity, altered protein structure Leishmania donovani
5.3.1.6 H138N 82% loss of enzyme activity, altered protein structure Leishmania donovani
5.3.1.6 P47A 30.7% loss of enzyme activity, altered protein structure Leishmania donovani
5.3.1.6 Y46F similar kinetic behaviour as wild type, but altered protein structure Leishmania donovani

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.3.1.6 2.51
-
D-ribose 5-phosphate wild-type, pH 7.5, 22°C Leishmania donovani
5.3.1.6 2.59
-
D-ribose 5-phosphate mutant Y46F, pH 7.5, 22°C Leishmania donovani
5.3.1.6 3.4
-
D-ribose 5-phosphate mutant H11N, pH 7.5, 22°C Leishmania donovani
5.3.1.6 4.3
-
D-ribose 5-phosphate mutant P47A, pH 7.5, 22°C Leishmania donovani
5.3.1.6 8.14
-
D-ribose 5-phosphate mutant H138N, pH 7.5, 22°C Leishmania donovani

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.6 Leishmania donovani G9JM00
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.6 D-allose
-
Leishmania donovani D-psicose
-
?
5.3.1.6 D-Arabinose
-
Leishmania donovani ?
-
?
5.3.1.6 D-ribose
-
Leishmania donovani D-ribulose
-
?
5.3.1.6 D-ribose 5-phosphate
-
Leishmania donovani D-ribulose 5-phosphate
-
?
5.3.1.6 D-talose
-
Leishmania donovani D-tagatose
-
?
5.3.1.6 additional information enzyme exhibits activity with D-form of various aldose substrates in the order of D-ribose > D-talose > D-allose > D-arabinose Leishmania donovani ?
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.3.1.6 11
-
D-ribose 5-phosphate mutant H138N, pH 7.5, 22°C Leishmania donovani
5.3.1.6 18
-
D-ribose 5-phosphate mutant P47A, pH 7.5, 22°C Leishmania donovani
5.3.1.6 25
-
D-ribose 5-phosphate mutant Y46F, pH 7.5, 22°C Leishmania donovani
5.3.1.6 29
-
D-ribose 5-phosphate wild-type, pH 7.5, 22°C Leishmania donovani
5.3.1.6 32
-
D-ribose 5-phosphate mutant H11N, pH 7.5, 22°C Leishmania donovani

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
5.3.1.6 1.35
-
D-ribose 5-phosphate mutant H138N, pH 7.5, 22°C Leishmania donovani
5.3.1.6 4.24
-
D-ribose 5-phosphate mutant P47A, pH 7.5, 22°C Leishmania donovani
5.3.1.6 9.51
-
D-ribose 5-phosphate mutant H11N, pH 7.5, 22°C Leishmania donovani
5.3.1.6 9.82
-
D-ribose 5-phosphate mutant Y46F, pH 7.5, 22°C Leishmania donovani
5.3.1.6 11.175
-
D-ribose 5-phosphate wild-type, pH 7.5, 22°C Leishmania donovani