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Literature summary extracted from

  • El-Azaz, J.; de la Torre, F.; Avila, C.; Canovas, F.M.
    Identification of a small protein domain present in all plant lineages that confers high prephenate dehydratase activity (2016), Plant J., 87, 215-229 .
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.51 0.15
-
 prephenate pH 8.0, 37°C Pinus pinaster
4.2.1.51 0.3
-
 prephenate pH 8.0, 37°C, prephenate dehydratase Cmut1 Pinus pinaster
4.2.1.51 0.34
-
 prephenate pH 8.0, 37°C Pinus pinaster
4.2.1.51 2.11
-
 prephenate pH 8.0, 37°C, prephenate dehydratase Gmut11 Pinus pinaster
4.2.1.51 2.15
-
 prephenate pH 8.0, 37°C, prephenate dehydratase Gmut9 Pinus pinaster
4.2.1.51 2.72
-
 prephenate pH 8.0, 37°C Pinus pinaster

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.51 Pinus pinaster
-
-
-
4.2.1.51 Pinus pinaster A0A1I9WKA1
-
-
4.2.1.51 Pinus pinaster A0A1I9WKA2
-
-
4.2.1.51 Pinus pinaster A0A1I9WKA6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.51 prephenate
-
 Pinus pinaster phenylpyruvate + H2O + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.51 Cmut1
-
 Pinus pinaster
4.2.1.51 Gmut11
-
 Pinus pinaster
4.2.1.51 Gmut9
-
 Pinus pinaster
4.2.1.51 PpADT-B
-
 Pinus pinaster
4.2.1.51 PpADT-C
-
 Pinus pinaster
4.2.1.51 PpADT-G
-
 Pinus pinaster

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.51 0.031
-
 prephenate pH 8.0, 37°C, prephenate dehydratase Cmut1 Pinus pinaster
4.2.1.51 0.036
-
 prephenate pH 8.0, 37°C, prephenate dehydratase Gmut11 Pinus pinaster
4.2.1.51 0.04
-
 prephenate pH 8.0, 37°C Pinus pinaster
4.2.1.51 0.04
-
 prephenate pH 8.0, 37°C, prephenate dehydratase Gmut9 Pinus pinaster
4.2.1.51 0.3539
-
 prephenate pH 8.0, 37°C Pinus pinaster
4.2.1.51 0.7158
-
 prephenate pH 8.0, 37°C Pinus pinaster

General Information

EC Number General Information Comment Organism
4.2.1.51 evolution all plant clades include PAC domain-containing arogenate dehydratases, suggesting that the prephenate dehydratase activity, and thus the ability to synthesize L-phenylalanine using phenylpyruvate as an intermediate, has been preserved throughout the evolution of plants. This pathway together with the arogenate pathway gives plants a broad and versatile capacity to synthesize L-phenylalanine and its derived compounds Pinus pinaster
4.2.1.51 metabolism the enzyme is involved in the phenylpyruvate biosynthetic pathway Pinus pinaster

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.2.1.51 14.7
-
 prephenate pH 8.0, 37°C Pinus pinaster
4.2.1.51 17.14
-
 prephenate pH 8.0, 37°C, prephenate dehydratase Gmut11 Pinus pinaster
4.2.1.51 18.6
-
 prephenate pH 8.0, 37°C, prephenate dehydratase Gmut9 Pinus pinaster
4.2.1.51 103.3
-
 prephenate pH 8.0, 37°C, prephenate dehydratase Cmut1 Pinus pinaster
4.2.1.51 1040.8
-
 prephenate pH 8.0, 37°C Pinus pinaster
4.2.1.51 4772.1
-
 prephenate pH 8.0, 37°C Pinus pinaster