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Literature summary extracted from

  • Zhang, D.H.; Li, N.; Yu, X.; Zhao, P.; Li, T.; Xu, J.W.
    Overexpression of the homologous lanosterol synthase gene in ganoderic acid biosynthesis in Ganoderma lingzhi (2017), Phytochemistry, 134, 46-53 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.99.7 LS gene from Ganoderma lingzhi, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, recombinant overexpression in Ganoderma lucidum, subcloning in Escherichia coli strain JM109, quantitative real-time PCR enzyme expression analysis Ganoderma lucidum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.99.7 (3S)-2,3-epoxy-2,3-dihydrosqualene Ganoderma lucidum
-
 lanosterol
-
 r
5.4.99.7 (3S)-2,3-epoxy-2,3-dihydrosqualene Ganoderma lucidum CGMCC 5.616
-
 lanosterol
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.7 Ganoderma lucidum A0A1L5JY50 Ganoderma lucidum strain CGMCC 5.616 is conspecific with Ganoderma lingzhi according to the molecular phylogenetic approach
-
5.4.99.7 Ganoderma lucidum CGMCC 5.616 A0A1L5JY50 Ganoderma lucidum strain CGMCC 5.616 is conspecific with Ganoderma lingzhi according to the molecular phylogenetic approach
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.99.7 mycelium submerged culture Ganoderma lucidum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.7 (3S)-2,3-epoxy-2,3-dihydrosqualene
-
 Ganoderma lucidum lanosterol
-
 r
5.4.99.7 (3S)-2,3-epoxy-2,3-dihydrosqualene
-
 Ganoderma lucidum CGMCC 5.616 lanosterol
-
 r

Subunits

EC Number Subunits Comment Organism
5.4.99.7 ? x * 82700, about, sequence calculation Ganoderma lucidum

pI Value

EC Number Organism Comment pI Value Maximum pI Value
5.4.99.7 Ganoderma lucidum sequence calculation
-
 6.26

General Information

EC Number General Information Comment Organism
5.4.99.7 additional information determination of ganoderic acids and lanosterol in mycelia Ganoderma lucidum
5.4.99.7 physiological function lanosterol is a common precursor in the biosynthesis of ganoderic acids and ergosterol in Ganoderma lingzhi Ganoderma lucidum