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Literature summary extracted from

  • Karacan, M.S.; Rodionova, M.V.; Tunc, T.; Venedik, K.B.; Mamas, S.; Shitov, A.V.; Zharmukhamedov, S.K.; Klimov, V.V.; Karacan, N.; Allakhverdiev, S.I.
    Characterization of nineteen antimony(III) complexes as potent inhibitors of photosystem II, carbonic anhydrase, and glutathione reductase (2016), Photosynth. Res., 130, 167-182 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 1,1'-(tribromo-lambda5-stibanediyl)bis(2-aminopyridin-1-ium) 29.9% inhibition of CO2 hydration reaction after 30 min Bos taurus
4.2.1.1 1,1'-(tribromo-lambda5-stibanediyl)bis(2-aminopyridin-1-ium) 31.6% inhibition of CO2 hydration reaction after 30 min Pisum sativum
4.2.1.1 1,1'-(tribromo-lambda5-stibanediyl)bis(2-aminopyrimidin-1-ium) 57.6% inhibition of CO2 hydration reaction after 30 min Bos taurus
4.2.1.1 1,1'-(tribromo-lambda5-stibanediyl)bis(2-aminopyrimidin-1-ium) 16.3% inhibition of CO2 hydration reaction after 30 min Pisum sativum
4.2.1.1 1,1'-(trichloro-lambda5-stibanediyl)bis(2-amino-4,6-dimethoxy-5-sulfanylpyrimidin-1-ium) 99.3% inhibition of CO2 hydration reaction after 30 min Bos taurus
4.2.1.1 1,1'-(trichloro-lambda5-stibanediyl)bis(2-amino-4,6-dimethoxy-5-sulfanylpyrimidin-1-ium) 64.8% inhibition of CO2 hydration reaction after 30 min Pisum sativum
4.2.1.1 1,1'-(trichloro-lambda5-stibanediyl)bis(2-aminopyridin-1-ium) 49.2% inhibition of CO2 hydration reaction after 30 min Bos taurus
4.2.1.1 1,1'-(trichloro-lambda5-stibanediyl)bis(2-aminopyridin-1-ium) 9.4% inhibition of CO2 hydration reaction after 30 min Pisum sativum
4.2.1.1 1,1'-(trichloro-lambda5-stibanediyl)bis(2-aminopyrimidin-1-ium) 98.4% inhibition of CO2 hydration reaction after 30 min Bos taurus
4.2.1.1 1,1'-(trichloro-lambda5-stibanediyl)bis(2-aminopyrimidin-1-ium) 90.2% inhibition of CO2 hydration reaction after 30 min Pisum sativum
4.2.1.1 1,1'-(trichloro-lambda5-stibanediyl)bis[2-amino-4,6-dimethoxy-5-[(1H-tetrazol-5-yl)sulfanyl]pyrimidin-1-ium] 14.3% inhibition of CO2 hydration reaction after 30 min Pisum sativum
4.2.1.1 12,12,12-tribromo-7-oxo-6,7a,8,9,10,12-hexahydro-7H-12lambda5-pyrrolo[1',2':1,7][1,3,5,2]triazastibepino[4,3-b][1,3]benzothiazol-13-ium 92.3% inhibition of CO2 hydration reaction after 30 min Bos taurus
4.2.1.1 12,12,12-tribromo-7-oxo-6,7a,8,9,10,12-hexahydro-7H-12lambda5-pyrrolo[1',2':1,7][1,3,5,2]triazastibepino[4,3-b][1,3]benzothiazol-13-ium 11.1% inhibition of CO2 hydration reaction after 30 min; 18.4% inhibition of CO2 hydration reaction after 30 min Pisum sativum
4.2.1.1 2-[[(5-chlorothiophen-2-yl)(hydroxy)methyl]amino]-1-(trichloro[2-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]pyrimidin-1-ium-1-yl]-lambda5-stibanyl)pyrimidin-1-ium 18.7% inhibition of CO2 hydration reaction after 30 min Bos taurus
4.2.1.1 2-[[(5-chlorothiophen-2-yl)(hydroxy)methyl]amino]-1-(trichloro[2-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]pyrimidin-1-ium-1-yl]-lambda5-stibanyl)pyrimidin-1-ium 62.5% inhibition of CO2 hydration reaction after 30 min Pisum sativum
4.2.1.1 3-amino-1,1,1-tribromo-4,5-dihydro-1H-1lambda5-[1,3,5,2]triazastibinino[1,6-a]benzimidazol-10-ium 35% inhibition of CO2 hydration reaction after 30 min Bos taurus
4.2.1.1 3-amino-1,1,1-trichloro-4,5-dihydro-1H-1lambda5-[1,3,5,2]triazastibinino[1,6-a]benzimidazol-10-ium 10.0% inhibition of CO2 hydration reaction after 30 min Pisum sativum
4.2.1.1 5,5,5-tribromo-1,2,3,7,8,9,9a,11,16,17a-decahydro-5H-5lambda5-dipyrrolo[2,1-c:1',2'-f][1,4,6,9,5]benzotetraazastibacycloundecine-10,17-dione 83.9% inhibition of CO2 hydration reaction after 30 min Bos taurus
4.2.1.1 5,5,5-tribromo-1,2,3,7,8,9,9a,11,16,17a-decahydro-5H-5lambda5-dipyrrolo[2,1-c:1',2'-f][1,4,6,9,5]benzotetraazastibacycloundecine-10,17-dione 9.9% inhibition of CO2 hydration reaction after 30 min Pisum sativum
4.2.1.1 6,6,6-trichloro-11-oxo-8,9,10,10a,11,12-hexahydro-6H-6lambda5-pyrimido[1,2-c]pyrrolo[2,1-g][1,3,5,2]triazastibepin-5-ium 31.0% inhibition of CO2 hydration reaction after 30 min Bos taurus
4.2.1.1 6,6,6-trichloro-11-oxo-8,9,10,10a,11,12-hexahydro-6H-6lambda5-pyrimido[1,2-c]pyrrolo[2,1-g][1,3,5,2]triazastibepin-5-ium 25.1% inhibition of CO2 hydration reaction after 30 min Pisum sativum
4.2.1.1 6-chloro-6,6-dimethyl-12-oxo-6,8,9,10,11,11a,12,13-octahydro-6lambda5-pyrido[2,1-g]pyrimido[1,2-c][1,3,5,2]triazastibepin-5-ium 99.3% inhibition of CO2 hydration reaction after 30 min Bos taurus
4.2.1.1 6-chloro-6,6-dimethyl-12-oxo-6,8,9,10,11,11a,12,13-octahydro-6lambda5-pyrido[2,1-g]pyrimido[1,2-c][1,3,5,2]triazastibepin-5-ium 22.9% inhibition of CO2 hydration reaction after 30 min Pisum sativum
4.2.1.1 dibenzyl N',N'''-(tribromo-lambda5-stibanediyl)biscarbamimidothioate 36.0% inhibition of CO2 hydration reaction after 30 min Bos taurus
4.2.1.1 dibenzyl N',N'''-(trichloro-lambda5-stibanediyl)biscarbamimidothioate 26.7% inhibition of CO2 hydration reaction after 30 min Bos taurus
4.2.1.1 dibenzyl N',N'''-(trichloro-lambda5-stibanediyl)biscarbamimidothioate 54.4% inhibition of CO2 hydration reaction after 30 min Pisum sativum
4.2.1.1 additional information antimony(III) complexes inhibit alpha-carbonic anhydrase isozyme II from bovine erythrocytes. No inhibition by 5 Bos taurus
4.2.1.1 additional information antimony(III) complexes inhibit glutathione reductase activity of chloroplast, and a number of them also exhibit good inhibitory efficiency against the photosynthetic and carbonic anhydrase activity of Pisum sativum photosystem II Pisum sativum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.1 chloroplast
-
 Pisum sativum 9507
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.1 Zn2+ required, metalloenzyme Bos taurus
4.2.1.1 Zn2+ required, metalloenzyme Pisum sativum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.1 H2CO3 Bos taurus
-
 CO2 + H2O
-
 r
4.2.1.1 H2CO3 Pisum sativum
-
 CO2 + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Bos taurus P00921
-
-
4.2.1.1 Pisum sativum P17067
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.1 commercial preparation
-
 Bos taurus
-
4.2.1.1 erythrocyte
-
 Bos taurus
-
4.2.1.1 leaf
-
 Pisum sativum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 H2CO3
-
 Bos taurus CO2 + H2O
-
 r
4.2.1.1 H2CO3
-
 Pisum sativum CO2 + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 alpha-CA
-
 Bos taurus
4.2.1.1 alpha-carbonic anhydrase isozyme II
-
 Bos taurus
4.2.1.1 CAA
-
 Pisum sativum