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Literature summary extracted from

  • Pergolizzi, G.; Cominetti, M.M.; Butt, J.N.; Field, R.A.; Bowater, R.P.; Wagner, G.K.
    Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligases (2015), Org. Biomol. Chem., 13, 6380-6398 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.2 2-iodo-AMP
-
 Escherichia coli
6.5.1.2 2-iodo-AMP
-
 Mycobacterium tuberculosis
6.5.1.2 2-iodo-NAD+
-
 Escherichia coli
6.5.1.2 2-iodo-NAD+
-
 Mycobacterium tuberculosis
6.5.1.2 2-phenyl-NAD+
-
 Escherichia coli
6.5.1.2 2-phenyl-NAD+
-
 Mycobacterium tuberculosis
6.5.1.2 Quinacrine
-
 Escherichia coli
6.5.1.2 Quinacrine
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Escherichia coli
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Mycobacterium tuberculosis
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Mycobacterium tuberculosis H37Rv
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.2 Escherichia coli
-
-
-
6.5.1.2 Mycobacterium tuberculosis
-
-
-
6.5.1.2 Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Escherichia coli (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Mycobacterium tuberculosis (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Mycobacterium tuberculosis H37Rv (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.2 NAD(+)-dependent DNA ligase
-
 Escherichia coli
6.5.1.2 NAD(+)-dependent DNA ligase
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
6.5.1.2 NAD+
-
 Escherichia coli
6.5.1.2 NAD+
-
 Mycobacterium tuberculosis