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Literature summary extracted from
- Structure of the human multidrug transporter ABCG2 (2017), Nature, 546, 504-509 .
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 7.6.2.2 | E211Q | inactive | Homo sapiens |
| 7.6.2.2 | Y432A | the mutation disrupts in vivo cholesterol transport | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.6.2.2 | antibody 5D3 | - |
Homo sapiens | |
| 7.6.2.2 | Ko143 | - |
Homo sapiens |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 7.6.2.2 | 144000 | - |
gel filtration | Homo sapiens |
| 7.6.2.2 | 250000 | - |
ABCG2-5D3(Fab) complex, gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.2 | ATP + H2O + cholesterol[side 1] | Homo sapiens | the enzyme does not catalyze significant cholesterol transport in vivo | ADP + phosphate + cholesterol[side 2] | - |
? | |
| 7.6.2.2 | ATP + H2O + xenobiotic[side 1] | Homo sapiens | - |
ADP + phosphate + xenobiotic[side 2] | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.6.2.2 | Homo sapiens | Q9UNQ0 | - |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 7.6.2.2 | glycoprotein | the enzyme is N-glycosylated at N596 | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.6.2.2 | HEK-293 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.2 | ATP + H2O + cholesterol[side 1] | the enzyme does not catalyze significant cholesterol transport in vivo | Homo sapiens | ADP + phosphate + cholesterol[side 2] | - |
? | |
| 7.6.2.2 | ATP + H2O + estrone-3-sulfate[side 1] | - |
Homo sapiens | ADP + phosphate + estrone-3-sulfate[side 2] | - |
? | |
| 7.6.2.2 | ATP + H2O + xenobiotic[side 1] | - |
Homo sapiens | ADP + phosphate + xenobiotic[side 2] | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 7.6.2.2 | homodimer | cryo-electron microscopy | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.6.2.2 | ABCG2 | - |
Homo sapiens |
| 7.6.2.2 | multidrug transporter | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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