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Literature summary extracted from

  • Popow, J.; Jurkin, J.; Schleiffer, A.; Martinez, J.
    Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors (2014), Nature, 511, 104-107 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.5.1.8 archease archease stimulates the activity of the human tRNA ligase complex with high efficiency only in the presence of GTP Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
6.5.1.8 E371Q the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
6.5.1.8 H601Q the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
6.5.1.8 K52N the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
6.5.1.8 R557K the mutant shows reduced activity compared to the wild type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.8 (ribonucleotide)n-2',3'-cyclophosphate + 5'-hydroxy-(ribonucleotide)m + GTP + H2O Homo sapiens
-
 (ribonucleotide)n+m + GMP + diphosphate
-
 ?
6.5.1.8 (ribonucleotide)n-3'-phosphate + 5'-hydroxy-(ribonucleotide)m + GTP Homo sapiens
-
 (ribonucleotide)n+m + GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.5.1.8 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.8 (ribonucleotide)n-2',3'-cyclophosphate + 5'-hydroxy-(ribonucleotide)m + GTP + H2O
-
 Homo sapiens (ribonucleotide)n+m + GMP + diphosphate
-
 ?
6.5.1.8 (ribonucleotide)n-3'-phosphate + 5'-hydroxy-(ribonucleotide)m + GTP
-
 Homo sapiens (ribonucleotide)n+m + GMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.5.1.8 ? x * 60000, FLAG-tagged protein, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
6.5.1.8 rtcB subunit of tRNA splicing ligase, also known as HSPC117, C22orf28, FAAP, or D10Wsu52e Homo sapiens
6.5.1.8 tRNA splicing ligase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.5.1.8 GTP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
6.5.1.8 physiological function the enzyme operates during the unfolded protein response Homo sapiens