BRENDA - Enzyme Database

Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis

Nandakumar, M.; Nathan, C.; Rhee, K.Y.; Nat. Commun. 5, 4306 (2014)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.1.3.1
isocitrate
Mycobacterium tuberculosis
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium tuberculosis H37Rv
-
succinate + glyoxylate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.1.3.1
Mycobacterium tuberculosis
-
-
-
4.1.3.1
Mycobacterium tuberculosis H37Rv
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.3.1
isocitrate
-
748738
Mycobacterium tuberculosis
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
748738
Mycobacterium tuberculosis H37Rv
succinate + glyoxylate
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.1.3.1
isocitrate
Mycobacterium tuberculosis
-
succinate + glyoxylate
-
-
?
4.1.3.1
isocitrate
Mycobacterium tuberculosis H37Rv
-
succinate + glyoxylate
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.3.1
isocitrate
-
748738
Mycobacterium tuberculosis
succinate + glyoxylate
-
-
-
?
4.1.3.1
isocitrate
-
748738
Mycobacterium tuberculosis H37Rv
succinate + glyoxylate
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
4.1.3.1
malfunction
enzyme-deficient Mycobacterium tuberculosis strains are significantly more susceptible than wild type to the antibiotics isoniazid, rifampicin, and streptomycin
Mycobacterium tuberculosis
General Information (protein specific)
EC Number
General Information
Commentary
Organism
4.1.3.1
malfunction
enzyme-deficient Mycobacterium tuberculosis strains are significantly more susceptible than wild type to the antibiotics isoniazid, rifampicin, and streptomycin
Mycobacterium tuberculosis