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Literature summary extracted from

  • Wang, P.; Jiang, L.; Cao, Y.; Ye, D.; Zhou, L.
    The design and synthesis of n-xanthone benzenesulfonamides as novel phosphoglycerate mutase 1 (PGAM1) inhibitors (2018), Molecules, 23, E1396 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.2.11 2,6-dichloro-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11 3-chloro-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-2-fluorobenzenesulfonamide
-
Homo sapiens
5.4.2.11 4-(tert-butyl)-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11 4-chloro-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11 4-cyclohexyl-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11 6-([1,1'-biphenyl]-4-sulfonamido)-8-hydroxy-9-oxo-9H-xanthen-2-yl acetate
-
Homo sapiens
5.4.2.11 epigallocatechin gallate
-
Homo sapiens
5.4.2.11 gemcitabine
-
Homo sapiens
5.4.2.11 MJE3
-
Homo sapiens
5.4.2.11 N-(1,7-dihydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
Homo sapiens
5.4.2.11 N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-1-phenylmethanesulfonamide
-
Homo sapiens
5.4.2.11 N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-2-fluorobenzenesulfonamide
-
Homo sapiens
5.4.2.11 N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-3,5-difluorobenzenesulfonamide
-
Homo sapiens
5.4.2.11 N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-4-fluorobenzenesulfonamide
-
Homo sapiens
5.4.2.11 N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-4-iodobenzenesulfonamide
-
Homo sapiens
5.4.2.11 N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-4-methylbenzenesulfonamide
-
Homo sapiens
5.4.2.11 N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
Homo sapiens
5.4.2.11 N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
-
Homo sapiens
5.4.2.11 N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
-
Homo sapiens
5.4.2.11 N-(1-hydroxy-5-methoxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
Homo sapiens
5.4.2.11 N-(1-hydroxy-5-methyl-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
Homo sapiens
5.4.2.11 N-(1-hydroxy-7-methoxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
Homo sapiens
5.4.2.11 N-(1-hydroxy-7-methyl-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
Homo sapiens
5.4.2.11 N-(1-hydroxy-7-nitro-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
Homo sapiens
5.4.2.11 N-(1-hydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
Homo sapiens
5.4.2.11 N-(7-chloro-1-hydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
Homo sapiens
5.4.2.11 N-(7-fluoro-1-hydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
-
Homo sapiens
5.4.2.11 PGMI-004A
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.2.11 2-phospho-D-glycerate Homo sapiens
-
3-phospho-D-glycerate
-
?

Organism

EC Number Organism UniProt Comment Textmining
5.4.2.11 Homo sapiens P18669
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.2.11 2-phospho-D-glycerate
-
Homo sapiens 3-phospho-D-glycerate
-
?

Synonyms

EC Number Synonyms Comment Organism
5.4.2.11 PGAM1
-
Homo sapiens
5.4.2.11 phosphoglycerate mutase 1
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.4.2.11 0.000193
-
at pH 8.0 and 25°C Homo sapiens gemcitabine
5.4.2.11 0.00049
-
at pH 8.0 and 25°C Homo sapiens epigallocatechin gallate
5.4.2.11 0.0021
-
at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-7-nitro-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
5.4.2.11 0.0027
-
at pH 8.0 and 25°C Homo sapiens 6-([1,1'-biphenyl]-4-sulfonamido)-8-hydroxy-9-oxo-9H-xanthen-2-yl acetate
5.4.2.11 0.0035
-
at pH 8.0 and 25°C Homo sapiens N-(7-chloro-1-hydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
5.4.2.11 0.0046
-
at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-7-methoxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
5.4.2.11 0.0055
-
at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
5.4.2.11 0.0059
-
at pH 8.0 and 25°C Homo sapiens 4-cyclohexyl-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.006
-
at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)naphthalene-1-sulfonamide
5.4.2.11 0.0064
-
at pH 8.0 and 25°C Homo sapiens 3-chloro-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-2-fluorobenzenesulfonamide
5.4.2.11 0.0064
-
at pH 8.0 and 25°C Homo sapiens N-(1,7-dihydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
5.4.2.11 0.0065
-
at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-5-methoxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
5.4.2.11 0.008
-
at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-7-methyl-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
5.4.2.11 0.0084
-
at pH 8.0 and 25°C Homo sapiens 4-(tert-butyl)-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0086
-
at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-5-methyl-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
5.4.2.11 0.0101
-
at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-4-iodobenzenesulfonamide
5.4.2.11 0.0102
-
at pH 8.0 and 25°C Homo sapiens 2,6-dichloro-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.0131
-
at pH 8.0 and 25°C Homo sapiens PGMI-004A
5.4.2.11 0.0132
-
at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-3,5-difluorobenzenesulfonamide
5.4.2.11 0.0137
-
at pH 8.0 and 25°C Homo sapiens N-(7-fluoro-1-hydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
5.4.2.11 0.0143
-
at pH 8.0 and 25°C Homo sapiens N-(1-hydroxy-9-oxo-9H-xanthen-3-yl)-[1,1'-biphenyl]-4-sulfonamide
5.4.2.11 0.02
-
at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-4-methylbenzenesulfonamide
5.4.2.11 0.02
-
IC50 value above 0.02 mM, at pH 8.0 and 25°C Homo sapiens 4-chloro-N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.02
-
IC50 value above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-1-phenylmethanesulfonamide
5.4.2.11 0.02
-
IC50 value above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-2-fluorobenzenesulfonamide
5.4.2.11 0.02
-
IC50 value above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)-4-fluorobenzenesulfonamide
5.4.2.11 0.02
-
IC50 value above 0.02 mM, at pH 8.0 and 25°C Homo sapiens N-(1,8-dihydroxy-9-oxo-9H-xanthen-3-yl)benzenesulfonamide
5.4.2.11 0.033
-
at pH 8.0 and 25°C Homo sapiens MJE3