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Literature summary extracted from

  • Korycka-Machala, M.; Nowosielski, M.; Kuron, A.; Rykowski, S.; Olejniczak, A.; Hoffmann, M.; Dziadek, J.
    Naphthalimides selectively inhibit the activity of bacterial, replicative DNA ligases and display bactericidal effects against tubercle bacilli (2017), Molecules, 22, pii: E154 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.2 chaetochromin
-
 Mycobacterium tuberculosis
6.5.1.2 mitonafide i.e. 3-nitro-N-(2-(dimethylamino)ethyl)-1,8-naphthalimide Mycobacterium tuberculosis
6.5.1.2 pinafide i.e. 3-nitro-N-(2-(1-pyrrolidinyl)ethyl)-1,8-naphthalimide Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Mycobacterium tuberculosis
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Mycobacterium tuberculosis H37Rv
-
 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.2 Mycobacterium tuberculosis
-
-
-
6.5.1.2 Mycobacterium tuberculosis H37Rv
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.5.1.2 His-Bind column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Mycobacterium tuberculosis (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?
6.5.1.2 NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
 Mycobacterium tuberculosis H37Rv (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.2 LigA
-
 Mycobacterium tuberculosis
6.5.1.2 NAD+ DNA ligase
-
 Mycobacterium tuberculosis
6.5.1.2 NAD+-dependent DNA ligase A
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
6.5.1.2 NAD+
-
 Mycobacterium tuberculosis