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Literature summary extracted from

  • Moon, Y.S.; Kim, L.; Chun, H.S.; Lee, S.E.
    4-Hydroxy-7-methyl-3-phenylcoumarin suppresses aflatoxin biosynthesis via downregulation of aflk expressing versicolorin B synthase in aspergillus flavus (2017), Molecules, 22, 712 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.143 versiconal Aspergillus flavus
-
 versicolorin B + H2O
-
 ?
4.2.1.143 versiconal Aspergillus flavus ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167
-
 versicolorin B + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.143 Aspergillus flavus B8NHY3
-
-
4.2.1.143 Aspergillus flavus ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167 B8NHY3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.143 mycelium
-
 Aspergillus flavus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.143 versiconal
-
 Aspergillus flavus versicolorin B + H2O
-
 ?
4.2.1.143 versiconal
-
 Aspergillus flavus ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167 versicolorin B + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.143 aflK
-
 Aspergillus flavus

Expression

EC Number Organism Comment Expression
4.2.1.143 Aspergillus flavus thiabendazole, 4-hydroxy-7-methoxy-3-phenylcoumarin, 4-hydroxy-6,7-dimethylcoumarin, 6,7-dimethoxycoumarin, 4-(bromomethyl)-6,7-dimethoxycoumarin, and 1-(2-methylpiperidin-1-yl)-3-phenylprop-2-en-1-one show potent antifungal and antiaflatoxigenic activities against Aspergillus flavus. Inhibitory mode of antiaflatoxigenic action by 4-hydroxy-7-methyl-3-phenyl coumarin is based on the downregulation of aflD, aflK, aflQ, and aflR in aflatoxin biosynthesis. The inhibitory mode of antiaflatoxigenic action by 2,3-dihydrobenzofuran is based on the inhibition of the transcription factor (aflS) in the aflatoxin biosynthesis pathway. Complete inhibition of growth at 1 mg/ml down

General Information

EC Number General Information Comment Organism
4.2.1.143 metabolism genes aflD, aflK, aflQ, and aflR are involved in aflatoxin biosynthesis Aspergillus flavus