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Literature summary extracted from

  • Inami, Y.; Matsui, Y.; Hoshino, T.; Murayama, C.; Norimoto, H.
    Inhibitory activity of the flower buds of Lonicera japonica Thunb. against histamine production and L-histidine decarboxylase in human keratinocytes (2014), Molecules, 19, 8212-8219 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.22 enzyme expression analysis Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.22 53000
-
 active enzyme form Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.22 L-histidine Homo sapiens
-
 histamine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Homo sapiens P19113
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.22 epidermis
-
 Homo sapiens
-
4.1.1.22 keratinocyte epidermal, three-dimensional keratinocyte culture Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-histidine
-
 Homo sapiens histamine + CO2
-
 ?
4.1.1.22 additional information enzyme immunoassay for detection of histamine production Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.22 HDC
-
 Homo sapiens
4.1.1.22 L-Histidine decarboxylase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.22 pyridoxal 5'-phosphate
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
4.1.1.22 Homo sapiens both flower buds of Lonicera japonica and chlorogenic acid have inhibitory activities against the expression of 53-kDa HDC and histamine production in human epidermal keratinocytes. Chlorogenic acid shows a weaker effect on histamine production than that of flower buds of Lonicera japonica suggesting that other chemical constituents besides chlorogenic acid might contribute to the inhibitory activities. Chlorogenic acid might have an effect on the histamine production in other cells as well such as mast cells in addition to keratinocytes in the epidermis down