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Literature summary extracted from

  • Ohtoyo, M.; Tamura, M.; Machinaga, N.; Muro, F.; Hashimoto, R.
    Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency (2015), Mol. Cell. Biochem., 400, 125-133 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.2.27 2-acetyl-4-(tetrahydroxybutyl)imidazole the enzyme is inhibited indirectly by 2-acetyl-4-(tetrahydroxybutyl)imidazole under conditions of vitamin B6 deficiency Mus musculus
4.1.2.27 4-deoxypyridoxine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.27 sphinganine 1-phosphate Mus musculus
-
 phosphoethanolamine + palmitaldehyde
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.27 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.2.27 IT-79MTNC3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.27 sphinganine 1-phosphate
-
 Mus musculus phosphoethanolamine + palmitaldehyde
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.2.27 sphingosine 1-phosphate lyase
-
 Mus musculus
4.1.2.27 SPL
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.2.27 pyridoxal 5'-phosphate
-
 Mus musculus