EC Number | Application | Comment | Organism |
---|---|---|---|
2.3.1.275 | pharmacology | the PlsX/Y pathway defines the most widely distributed pathway for the initiation of phospholipid formation in bacteria and represents a target for the development of antibacterial therapeutics | Streptococcus pneumoniae |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.274 | expression in Escherichia coli | Streptococcus pneumoniae |
2.3.1.275 | expression in Escherichia coli | Streptococcus pneumoniae |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.274 | 0.14 | - |
phosphate | pH 7.4, 37°C | Streptococcus pneumoniae | |
2.3.1.274 | 0.3 | - |
hexadecanoyl-[acyl-carrier protein] | pH 7.4, 37°C | Streptococcus pneumoniae |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.275 | membrane | transmembrane protein with five membrane-spanning helices | Streptococcus pneumoniae | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.274 | Mg2+ | activity is modestly enhanced by Mg2+ but does not require a divalent cation | Streptococcus pneumoniae |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.274 | Streptococcus pneumoniae | Q8DRN3 | - |
- |
2.3.1.274 | Streptococcus pneumoniae ATCC BAA-255 | Q8DRN3 | - |
- |
2.3.1.275 | Streptococcus pneumoniae | P0A4Q0 | - |
- |
2.3.1.275 | Streptococcus pneumoniae ATCC BAA-255 | P0A4Q0 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.274 | - |
Streptococcus pneumoniae |
2.3.1.275 | recombinant His-tagged SpPlsY | Streptococcus pneumoniae |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.274 | hexadecanoyl-[acyl-carrier protein] + phosphate | the enzyme is involved in phosphatidic acid synthesis | Streptococcus pneumoniae | hexadecanoyl phosphate + an [acyl-carrier protein] | - |
? | |
2.3.1.274 | hexadecanoyl-[acyl-carrier protein] + phosphate | the enzyme is involved in phosphatidic acid synthesis | Streptococcus pneumoniae ATCC BAA-255 | hexadecanoyl phosphate + an [acyl-carrier protein] | - |
? | |
2.3.1.274 | additional information | the enzyme is specific for acyl-ACP, and acyl-CoA and free fatty acid are not substrates | Streptococcus pneumoniae | ? | - |
? | |
2.3.1.274 | additional information | the enzyme is specific for acyl-ACP, and acyl-CoA and free fatty acid are not substrates | Streptococcus pneumoniae ATCC BAA-255 | ? | - |
? | |
2.3.1.275 | palmitoyl phosphate + sn-glycerol 3-phosphate | - |
Streptococcus pneumoniae | 1-palmitoyl-sn-glycerol 3-phosphate + phosphate | - |
? | |
2.3.1.275 | palmitoyl phosphate + sn-glycerol 3-phosphate | - |
Streptococcus pneumoniae ATCC BAA-255 | 1-palmitoyl-sn-glycerol 3-phosphate + phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.274 | plsX | - |
Streptococcus pneumoniae |
2.3.1.274 | SPR0037 | - |
Streptococcus pneumoniae |
2.3.1.275 | SpPlsY protein | - |
Streptococcus pneumoniae |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.275 | 37 | - |
assay at | Streptococcus pneumoniae |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.275 | 7.4 | - |
assay at | Streptococcus pneumoniae |