EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.1 | additional information | neither phosphatidylinositol nor phosphatidylinositol 4-phosphate have any significant effect on the phosphatidylserine-stimulated ATPase activity of the enzyme | Bos taurus | |
7.6.2.1 | phosphatidylserine | - |
Bos taurus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
7.6.2.1 | expressed in PC-12 cells and HEK-293T cells | Bos taurus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
7.6.2.1 | S1138A | the mutant shows reduced activity compared to the wild type enzyme | Bos taurus |
7.6.2.1 | S1138D | the mutant shows slightly reduced activity compared to the wild type enzyme | Bos taurus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.1 | Ca2+ | - |
Bos taurus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
7.6.2.1 | Golgi apparatus | - |
Bos taurus | 5794 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.1 | ATP + H2O + phosphatidylserine[side 1] | Bos taurus | - |
ADP + phosphate + phosphatidylserine[side 2] | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.6.2.1 | Bos taurus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
7.6.2.1 | phosphoprotein | the enzyme undergoes phosphorylation on the serine residue within a CaMKII target motif | Bos taurus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.1 | ATP + H2O + phosphatidylserine[side 1] | - |
Bos taurus | ADP + phosphate + phosphatidylserine[side 2] | - |
? | |
7.6.2.1 | additional information | no transport activity with phosphatidylinositol | Bos taurus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
7.6.2.1 | ? | x * 120000, SDS-PAGE | Bos taurus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.6.2.1 | Atp8a2 | - |
Bos taurus |
7.6.2.1 | P4-ATPase | - |
Bos taurus |
7.6.2.1 | phosphatidylserine flippase | - |
Bos taurus |
7.6.2.1 | phospholipid flippase | - |
Bos taurus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
7.6.2.1 | 2.75 | - |
at pH and °C | Bos taurus | Ca2+ |