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Literature summary extracted from

  • de Lima Stein, M.L.; Icimoto, M.Y.; de Castro Levatti, E.V.; Oliveira, V.; Straus, A.H.; Schenkman, S.
    Characterization and role of the 3-methylglutaconyl coenzyme A hidratase in Trypanosoma brucei (2017), Mol. Biochem. Parasitol., 214, 36-46 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.18 expression in Escherichia coli Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.18 mitochondrion mitochondrial matrix Trypanosoma brucei 5739
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Organism

EC Number Organism UniProt Comment Textmining
4.2.1.18 Trypanosoma brucei
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-
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4.2.1.18 Trypanosoma brucei Lister 427
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.18 bloodstream form enzyme is expressed in both insect and mammalian bloodstream forms of Trypanosoma brucei Trypanosoma brucei
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Synonyms

EC Number Synonyms Comment Organism
4.2.1.18 3-MGCoA-H
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 Trypanosoma brucei
4.2.1.18 Tb427.10.4000
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 Trypanosoma brucei
4.2.1.18 Tb427.10.4000 gene locus Trypanosoma brucei

General Information

EC Number General Information Comment Organism
4.2.1.18 physiological function the depletion of 3-MGCoA-H by RNAi affects minimally the proliferation of both insect and mammalian bloodstream forms. An excess of leucine in the culture medium causes growth defects in cells depleted of 3-MGCoA-H, which can be reestablished by mevalonate. Procyclics depleted of the 3-MGCoA-H present reduced levels of synthesized steroids relative to cholesterol that is scavenged by the parasite Trypanosoma brucei