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Literature summary extracted from

  • Ren, S.; Yue, Y.; Li, Y.; Guo, X.; Wang, S.
    Functional analyses of the versicolorin B synthase gene in Aspergillus flavus (2017), MicrobiologyOpen, 6, e00471 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.143 gene alfK, encoded in the gene cluster involved in aflatoxin biosynthesis, sequence comparisons and phylogenetic analysis and tree, RT-PCR enzyme expression analysis Aspergillus flavus

Protein Variants

EC Number Protein Variants Comment Organism
4.2.1.143 additional information aflK mutant construction by gene replacement. The aflK deletion-mutant DELTAaflK exhibits a significant decrease in sclerotial production and aflatoxin biosynthesis compared with wild-type and the complementation strain DELTAaflK::aflK. The mutation DELTAaflK does not affect the ability of Aspergillus flavus to infect seeds, but downregulates aflatoxin production after seed infection Aspergillus flavus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.143 versiconal Aspergillus flavus
-
 versicolorin B + H2O
-
 ?
4.2.1.143 versiconal Aspergillus flavus ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167
-
 versicolorin B + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.143 Aspergillus flavus B8NHY3
-
-
4.2.1.143 Aspergillus flavus ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167 B8NHY3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.143 versiconal
-
 Aspergillus flavus versicolorin B + H2O
-
 ?
4.2.1.143 versiconal
-
 Aspergillus flavus ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167 versicolorin B + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.143 aflK
-
 Aspergillus flavus

General Information

EC Number General Information Comment Organism
4.2.1.143 malfunction conidiation phenotype and sclerotial phenotype of wild-type, enzyme deletion DELTAaflK, and complemented mutant DELTA aflK::aflK strains, overview. The aflK deletion-mutant DELTAaflK exhibits a significant decrease in sclerotial production and aflatoxin biosynthesis compared with wild-type and the complementation strain DELTAaflK::aflK. The mutation DELTAaflK does not affect the ability of Aspergillus flavus to infect seeds, but downregulates aflatoxin production after seed infection Aspergillus flavus
4.2.1.143 physiological function the enzyme is encoded by gene alfK, which is part of the gene cluster involved in aflatoxin biosynthesis. Negative role of aflK in sclerotial production. Relationship between enzyme AflK and sclerotial production in Aspergillus flavus Aspergillus flavus