EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
5.3.99.3 | glutathione | - |
Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
5.3.99.3 | medicine | enzyme inhibition can be useful for treating pain, fever, and anorexia | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
5.3.99.3 | expressed in A-549 cells, HeLa cells, HEK-293 cells, RAW 264.7 cells, Pichia pastoris strain KM71H, and Sf9 insect cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.3.99.3 | 3-(4-dodecanoyl-1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)propanoic acid | - |
Homo sapiens | |
5.3.99.3 | 4-(3-chlorobenzyl)-2,6-bis[4-(trifluoromethoxy)phenyl]-4H-thieno[3,2-b]pyrrole-5-carboxylic acid | - |
Homo sapiens | |
5.3.99.3 | AF3442 | - |
Homo sapiens | |
5.3.99.3 | licofelone | - |
Homo sapiens | |
5.3.99.3 | Oxacillin | - |
Homo sapiens | |
5.3.99.3 | YS121 | reversible and noncompetitive inhibition | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
5.3.99.3 | microsome | - |
Homo sapiens | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.3 | Prostaglandin H2 | Homo sapiens | - |
Prostaglandin E2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.3.99.3 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
5.3.99.3 | epididymis | - |
Homo sapiens | - |
5.3.99.3 | epithelial cell | - |
Homo sapiens | - |
5.3.99.3 | seminal vesicle | - |
Homo sapiens | - |
5.3.99.3 | Sertoli cell | - |
Homo sapiens | - |
5.3.99.3 | spermatocyte | - |
Homo sapiens | - |
5.3.99.3 | spermatogonium | - |
Homo sapiens | - |
5.3.99.3 | vas deferens | ampulla | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.3 | Prostaglandin H2 | - |
Homo sapiens | Prostaglandin E2 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
5.3.99.3 | homotrimer | - |
Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.3.99.3 | microsomal prostaglandin E2 synthase-1 | - |
Homo sapiens |
5.3.99.3 | mPGES-1 | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
5.3.99.3 | 0.0034 | - |
pH and temperature not specified in the publication | Homo sapiens | YS121 | |
5.3.99.3 | 0.006 | - |
pH and temperature not specified in the publication | Homo sapiens | licofelone |
EC Number | Organism | Comment | Expression |
---|---|---|---|
5.3.99.3 | Homo sapiens | the enzyme shows elevated levels in the cartilages and chondrocytes of patients suffering from osteoarthritis. The enzyme is overexpressed in 80% of several cancer cells | up |