Literature summary extracted from

Li, F.; Xu, D.
Functional role of R462 in the degradation of hyaluronan catalyzed by hyaluronate lyase from Streptococcus pneumoniae (2015), J. Mol. Model., 21, 196 .

Protein Variants

EC Number	Protein Variants	Comment	Organism
4.2.2.1	R462A	modeling of site directed mutagenesis simulations of R462A and R462Q. The energetic profiles for the reaction processes are essentially the same as that in wild type enzyme, but the mutation accelerates the overall enzymatic activity. R462A can reduce the barrier height by about 2.8 kcal/mol. The positive charge on the R462 guanidino side chain group plays a negative role in the catalysis	Streptococcus pneumoniae
4.2.2.1	R462Q	modeling of site directed mutagenesis simulations of R462A and R462Q. The energetic profiles for the reaction processes are essentially the same as that in wild type enzyme, but the mutation accelerates the overall enzymatic activity. R462Q can reduce the barrier height by about 2.9 kcal/mol. The positive charge on the R462 guanidino side chain group plays a negative role in the catalysis	Streptococcus pneumoniae

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.2.2.1	Streptococcus pneumoniae	Q54873	serotype 4	-

Synonyms

EC Number	Synonyms	Comment	Organism
4.2.2.1	SP_0314	-	Streptococcus pneumoniae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)