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Literature summary extracted from

  • Xu, J.; Zhang, J.; Guo, Y.; Zhang, W.
    Genetically modifying aspartate aminotransferase and aspartate ammonia-lyase affects metabolite accumulation in L-lysine producing strain derived from Corynebacterium glutamicum ATCC13032 (2015), J. Mol. Catal. B, 113, 82-89 .
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.3.1.1 although Corynebacterium glutamicum posses the aspartate ammonia-lyase gene (aspA), aspartate aminotransferase (AAT) is necessary to cell growth and L-lysine production, because the activity of Corynebacterium glutamicum aspartate ammonia-lyase (AAL) is too low to maintain the cell growth. Escherichia coli aspartate ammonia-lyase helps to restore the cell growth of aspB-deleted strain and also leads to the accumulation of L-lysine, L-glutamate, pyruvate and 2-oxoglutarate Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.3.1.1 52000
-
 SDS-PAGE Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.1 fumarate + NH3 Escherichia coli important enzyme in production of L-aspartate L-aspartate
-
 r
4.3.1.1 fumarate + NH3 Escherichia coli MG1655 important enzyme in production of L-aspartate L-aspartate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.1 Escherichia coli P0AC38
-
-
4.3.1.1 Escherichia coli MG1655 P0AC38
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.1 fumarate + NH3
-
 Escherichia coli L-aspartate
-
 r
4.3.1.1 fumarate + NH3 important enzyme in production of L-aspartate Escherichia coli L-aspartate
-
 r
4.3.1.1 fumarate + NH3
-
 Escherichia coli MG1655 L-aspartate
-
 r
4.3.1.1 fumarate + NH3 important enzyme in production of L-aspartate Escherichia coli MG1655 L-aspartate
-
 r
4.3.1.1 L-aspartate
-
 Escherichia coli fumarate + NH3
-
 r
4.3.1.1 L-aspartate
-
 Escherichia coli MG1655 fumarate + NH3
-
 r

Subunits

EC Number Subunits Comment Organism
4.3.1.1 ? x * 52000, SDS-PAGE Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
4.3.1.1 ASPA
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
4.3.1.1 metabolism important enzyme in production of L-aspartate Escherichia coli